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Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia.

dc.contributor.authorMenasce, Lia P
dc.contributor.authorOrphanos, Vassilis
dc.contributor.authorSantibanez-Koref, Mauro F
dc.contributor.authorBoyle, John M
dc.contributor.authorHarrison, Christine J
dc.date.accessioned2010-04-26T09:15:03Z
dc.date.available2010-04-26T09:15:03Z
dc.date.issued1994-05
dc.identifier.citationDeletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia. 1994, 10 (1):26-9 Genes Chromosomes Canceren
dc.identifier.issn1045-2257
dc.identifier.pmid7519870
dc.identifier.doi10.1002/gcc.2870100105
dc.identifier.urihttp://hdl.handle.net/10541/97360
dc.description.abstractWe have characterised a region of deletion on the long arm of chromosome 6 (6q) in six cases of acute lymphoblastic leukaemia, by fluorescence in situ hybridisation, using a series of YAC clones which map to 6q. Conventional cytogenetic analysis of four of these cases had been interpreted as showing terminal deletions of 6q. We demonstrated by FISH that in all cases the deletions were interstitial. D6S246 (6q16.3) was the only marker which was missing in all six cases, indicating a common region of deletion between the markers M6P1 at 6q14-15 and FYN at 6q21. Our results suggest the presence of a tumour suppressor gene within this interval.
dc.language.isoenen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshChromosome Deletion
dc.subject.meshChromosomes, Artificial, Yeast
dc.subject.meshChromosomes, Human, Pair 6
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIn Situ Hybridization, Fluorescence
dc.subject.meshMale
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma
dc.titleDeletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital, Manchester, United Kingdom.en
dc.identifier.journalGenes, Chromosomes & Canceren
html.description.abstractWe have characterised a region of deletion on the long arm of chromosome 6 (6q) in six cases of acute lymphoblastic leukaemia, by fluorescence in situ hybridisation, using a series of YAC clones which map to 6q. Conventional cytogenetic analysis of four of these cases had been interpreted as showing terminal deletions of 6q. We demonstrated by FISH that in all cases the deletions were interstitial. D6S246 (6q16.3) was the only marker which was missing in all six cases, indicating a common region of deletion between the markers M6P1 at 6q14-15 and FYN at 6q21. Our results suggest the presence of a tumour suppressor gene within this interval.


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