• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Menasce, Lia P
    Orphanos, Vassilis
    Santibanez-Koref, Mauro F
    Boyle, John M
    Harrison, Christine J
    Affiliation
    Department of Histopathology, Christie Hospital, Manchester, United Kingdom.
    Issue Date
    1994-05
    
    Metadata
    Show full item record
    Abstract
    We have characterised a region of deletion on the long arm of chromosome 6 (6q) in six cases of acute lymphoblastic leukaemia, by fluorescence in situ hybridisation, using a series of YAC clones which map to 6q. Conventional cytogenetic analysis of four of these cases had been interpreted as showing terminal deletions of 6q. We demonstrated by FISH that in all cases the deletions were interstitial. D6S246 (6q16.3) was the only marker which was missing in all six cases, indicating a common region of deletion between the markers M6P1 at 6q14-15 and FYN at 6q21. Our results suggest the presence of a tumour suppressor gene within this interval.
    Citation
    Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia. 1994, 10 (1):26-9 Genes Chromosomes Cancer
    Journal
    Genes, Chromosomes & Cancer
    URI
    http://hdl.handle.net/10541/97360
    DOI
    10.1002/gcc.2870100105
    PubMed ID
    7519870
    Type
    Article
    Language
    en
    ISSN
    1045-2257
    ae974a485f413a2113503eed53cd6c53
    10.1002/gcc.2870100105
    Scopus Count
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Common region of deletion on the long arm of chromosome 6 in non-Hodgkin's lymphoma and acute lymphoblastic leukaemia.
    • Authors: Menasce LP, Orphanos V, Santibanez-Koref M, Boyle JM, Harrison CJ
    • Issue date: 1994 Aug
    • Analysis of chromosome 6 deletions in lymphoid malignancies provides evidence for a region of minimal deletion within a 2-megabase segment of 6q21.
    • Authors: Sherratt T, Morelli C, Boyle JM, Harrison CJ
    • Issue date: 1997 Apr
    • Deletion of 6q16-q21 in human lymphoid malignancies: a mapping and deletion analysis.
    • Authors: Jackson A, Carrara P, Duke V, Sinclair P, Papaioannou M, Harrison CJ, Foroni L
    • Issue date: 2000 Jun 1
    • Analysis of chromosome 6q deletion in EBV-associated NK cell leukaemia/lymphoma.
    • Authors: Ohshima K, Haraokaa S, Ishihara S, Ohgami A, Yoshioka S, Suzumiya J, Kikuchi M
    • Issue date: 2002 Feb
    • A 3-cM commonly deleted region in 6q21 in leukemias and lymphomas delineated by fluorescence in situ hybridization.
    • Authors: Zhang Y, Matthiesen P, Harder S, Siebert R, Castoldi G, Calasanz MJ, Wong KF, Rosenwald A, Ott G, Atkin NB, Schlegelberger B
    • Issue date: 2000 Jan
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.