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dc.contributor.authorSattar, A
dc.contributor.authorRooney, P
dc.contributor.authorKumar, Shant
dc.contributor.authorPye, David A
dc.contributor.authorWest, David C
dc.contributor.authorScott, I
dc.contributor.authorLedger, P
dc.date.accessioned2010-04-26T09:57:32Z
dc.date.available2010-04-26T09:57:32Z
dc.date.issued1994-10
dc.identifier.citationApplication of angiogenic oligosaccharides of hyaluronan increases blood vessel numbers in rat skin. 1994, 103 (4):576-9 J. Invest. Dermatol.en
dc.identifier.issn0022-202X
dc.identifier.pmid7523533
dc.identifier.doi10.1111/1523-1747.ep12396880
dc.identifier.urihttp://hdl.handle.net/10541/97344
dc.description.abstractAngiogenic oligosaccharides of hyaluronan were applied to the backs of young, adult male rats and the number of blood vessels, within a depth of 136 microns beneath the base of the epidermis, were evaluated. Application of hyaluronan oligosaccharides significantly increased the mean number of blood vessels/mm skin length in six of 11 treated rats when compared with controls. Application of radiolabeled hyaluronan oligosaccharides to skin of one rat demonstrated a penetration to a depth of approximately 800 microns, suggesting that the blood vessels beneath the epidermis would be exposed to the hyaluronan. Hyaluronan has previously been shown to stimulate endothelial cell proliferation; we demonstrate here that these hyaluronan oligosaccharides also specifically stimulate endothelial cell migration. This action of hyaluronan oligosaccharides may prove useful in retarding blood vessel paucity and degeneration observed during the ageing process and following radiotherapy.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshAorta
dc.subject.meshCattle
dc.subject.meshEndothelium, Vascular
dc.subject.meshHyaluronic Acid
dc.subject.meshMale
dc.subject.meshNeovascularization, Pathologic
dc.subject.meshOligosaccharides
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.subject.meshSkin
dc.titleApplication of angiogenic oligosaccharides of hyaluronan increases blood vessel numbers in rat skin.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathological Sciences, University of Manchester, U.K.en
dc.identifier.journalThe Journal of Investigative Dermatologyen
html.description.abstractAngiogenic oligosaccharides of hyaluronan were applied to the backs of young, adult male rats and the number of blood vessels, within a depth of 136 microns beneath the base of the epidermis, were evaluated. Application of hyaluronan oligosaccharides significantly increased the mean number of blood vessels/mm skin length in six of 11 treated rats when compared with controls. Application of radiolabeled hyaluronan oligosaccharides to skin of one rat demonstrated a penetration to a depth of approximately 800 microns, suggesting that the blood vessels beneath the epidermis would be exposed to the hyaluronan. Hyaluronan has previously been shown to stimulate endothelial cell proliferation; we demonstrate here that these hyaluronan oligosaccharides also specifically stimulate endothelial cell migration. This action of hyaluronan oligosaccharides may prove useful in retarding blood vessel paucity and degeneration observed during the ageing process and following radiotherapy.


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