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    Correlation of drug resistance-associated parameters in ovarian tumor biopsies.

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    Authors
    McGown, Alan T
    Murphy, D
    Swindell, Ric
    Crowther, Derek
    Fox, Brian W
    Affiliation
    CRC Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, and CRC Departments of Medical Oncology and Medical Statistics, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 9BX UK.
    Issue Date
    1994-07
    
    Metadata
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    Abstract
    This work compares glutathione levels, glutathione S-transferase activities and isoenzyme expression, metallothionein levels and P-glycoprotein expression in normal ovaries, and in epithelial ovarian tumor biopsies from patients prior to chemotherapy or following relapse. These parameters have been implicated as determinants of response to cytotoxic chemotherapy. Large differences were found between normal ovary and ovarian tumors, but no significant differences were observed between tumors taken before or after cytotoxic chemotherapy. These data do not support a role for these biochemical parameters in the decreased response seen in patients with recurrent or progressive disease.
    Citation
    Correlation of drug resistance-associated parameters in ovarian tumor biopsies. 1994, 4 (4):241-249 Int. J. Gynecol. Cancer
    Journal
    International Journal of Gynecological Cancer
    URI
    http://hdl.handle.net/10541/97339
    DOI
    10.1046/j.1525-1438.1994.04040241.x
    PubMed ID
    11578413
    Type
    Article
    Language
    en
    ISSN
    1525-1438
    ae974a485f413a2113503eed53cd6c53
    10.1046/j.1525-1438.1994.04040241.x
    Scopus Count
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    All Christie Publications
    All Paterson Institute for Cancer Research

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