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    VCAM-1 expression on reactive and tumour astrocytes.

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    Authors
    Kałuza, J
    Krupiński, J
    Kumar, Patricia
    Kumar, Shant
    Wang, Ji Min
    Affiliation
    Department of Neuropathology, Collegium Medicum, Jagiellonian University, Cracow, Poland.
    Issue Date
    1994
    
    Metadata
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    Abstract
    In our studies we used a monoclonal antibody recognizing the vascular adhesion molecule (VCAM-1). Tissue samples were collected at autopsy from human brain infarcts and from brain tumours, removed during surgical procedure (Neurological and Neurosurgical Clinic, Cracow). A novel, unexpected finding were VCAM-1-positive fibrous astrocytes in the stroke tissue, and astrocyte-like cells in the tumours. No staining was obtained either in the contralateral hemisphere or outside of ischemic areas. Likewise, no positive staining of cells was seen outside the tumour tissue. The above findings, taken together, strongly support the concept that astrocytes take part in the immune defense during various pathological processes in the human brain.
    Citation
    VCAM-1 expression on reactive and tumour astrocytes. 1994, 32 (1):17-20 Folia Histochem. Cytobiol.
    Journal
    Folia Histochemica et Cytobiologica
    URI
    http://hdl.handle.net/10541/97287
    PubMed ID
    7517897
    Type
    Article
    Language
    en
    ISSN
    0239-8508
    Collections
    All Christie Publications

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