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    Treatment evaluation of combined modality therapy: 'what can we obtain today from phase II trials?'.

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    Authors
    Thatcher, Nick
    Affiliation
    Christie Hospital, CRC Department of Medical Oncology, Manchester, UK.
    Issue Date
    1994-03
    
    Metadata
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    Abstract
    Demonstration of activity is the major goal of Phase II studies. Other end points-duration of response, survival (relapse free in complete responders), progression free interval, changes in performance status and quality of life also provide useful information. From these data a decision to continue or discard a particular therapy can be considered. Various handicaps including variability in response reporting, heterogeneity of patient populations, inadequate reporting of failure patterns, causes of death, performance status changes and quality of life hinder interpretation of Phase II data. Nevertheless, Phase II studies have defined prognostic groups, beneficial changes in performance status and have helped formulate novel management approaches. Targeting particular prognostic groups, investigating dose-intensive regimens with haemopoietic growth-factor support and novel combined-modality approaches have all been generated through Phase II investigations.
    Citation
    Treatment evaluation of combined modality therapy: 'what can we obtain today from phase II trials?'. 1994, 10 Suppl 1:S117-33 Lung Cancer
    Journal
    Lung Cancer
    URI
    http://hdl.handle.net/10541/97281
    DOI
    10.1016/0169-5002(94)91674-8
    PubMed ID
    8087501
    Type
    Article
    Language
    en
    ISSN
    0169-5002
    ae974a485f413a2113503eed53cd6c53
    10.1016/0169-5002(94)91674-8
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