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Stimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients.

dc.contributor.authorRoth, M
dc.contributor.authorRogers, S
dc.contributor.authorRoberts, S S
dc.contributor.authorBoyle, John M
dc.contributor.authorMüller, H J
dc.contributor.authorWeber, W
dc.date.accessioned2010-04-23T10:13:09Z
dc.date.available2010-04-23T10:13:09Z
dc.date.issued1994
dc.identifier.citationStimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients., 14 (3A):809-15 Anticancer Res.en
dc.identifier.issn0250-7005
dc.identifier.pmid8074483
dc.identifier.urihttp://hdl.handle.net/10541/97239
dc.description.abstractWe have used a monoclonal antibody specific for UV-induced 6-4 photoproducts in an ELISA assay to determine the kinetics of loss of antigenicity from the DNA of lymphocytes obtained from four groups of people; normal controls and cancer patients who had either received chemotherapy, hormone therapy or no treatment at all. This result was confirmed on a matched pairs analysis of 12 breast cancer patients sampled before and after chemotherapy. We conclude, that chemotherapeutic treatment with alkylating agents modulate the capacity of UV-induced DNA-repair in human lymphocytes in a yet unknown way.
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAlkylating Agents
dc.subject.meshAntineoplastic Agents
dc.subject.meshDNA
dc.subject.meshDNA Repair
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLymphocytes
dc.subject.meshMale
dc.subject.meshNeoplasms
dc.subject.meshUltraviolet Rays
dc.titleStimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients.en
dc.typeArticleen
dc.contributor.departmentDepartment of Research, University Hospital Basel, Switzerland.en
dc.identifier.journalAnticancer Researchen
html.description.abstractWe have used a monoclonal antibody specific for UV-induced 6-4 photoproducts in an ELISA assay to determine the kinetics of loss of antigenicity from the DNA of lymphocytes obtained from four groups of people; normal controls and cancer patients who had either received chemotherapy, hormone therapy or no treatment at all. This result was confirmed on a matched pairs analysis of 12 breast cancer patients sampled before and after chemotherapy. We conclude, that chemotherapeutic treatment with alkylating agents modulate the capacity of UV-induced DNA-repair in human lymphocytes in a yet unknown way.


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