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    Stimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients.

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    Authors
    Roth, M
    Rogers, S
    Roberts, S S
    Boyle, John M
    Müller, H J
    Weber, W
    Affiliation
    Department of Research, University Hospital Basel, Switzerland.
    Issue Date
    1994
    
    Metadata
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    Abstract
    We have used a monoclonal antibody specific for UV-induced 6-4 photoproducts in an ELISA assay to determine the kinetics of loss of antigenicity from the DNA of lymphocytes obtained from four groups of people; normal controls and cancer patients who had either received chemotherapy, hormone therapy or no treatment at all. This result was confirmed on a matched pairs analysis of 12 breast cancer patients sampled before and after chemotherapy. We conclude, that chemotherapeutic treatment with alkylating agents modulate the capacity of UV-induced DNA-repair in human lymphocytes in a yet unknown way.
    Citation
    Stimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients., 14 (3A):809-15 Anticancer Res.
    Journal
    Anticancer Research
    URI
    http://hdl.handle.net/10541/97239
    PubMed ID
    8074483
    Type
    Article
    Language
    en
    ISSN
    0250-7005
    Collections
    All Christie Publications

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