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    Pubertal growth in young adult survivors of childhood leukemia.

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    Authors
    Didcock, E
    Davies, H
    Didi, Mohammed
    Ogilvy-Stuart, Amanda L
    Wales, J
    Shalet, Stephen M
    Affiliation
    Department of Child Health, Queens Medical Centre, Nottingham, United Kingdom.
    Issue Date
    1995-10
    
    Metadata
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    Abstract
    PURPOSE: To determine the effect of cranial irradiation (18 Gy and 24 Gy) on pubertal growth in young adult survivors of childhood acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: Final height (FH) and pubertal growth were retrospectively examined in 142 young adult survivors of childhood ALL. All were in first remission and had received either 18 or 24 Gy of cranial irradiation. Eighty-four children (48 girls) were treated with 24 Gy and 58 (35 girls) with 18 Gy. None had received either testicular or spinal irradiation. Timing and duration of puberty were studied in 110 patients. RESULTS: Significant reduction in height standard deviation score (SDS) from diagnosis to FH was seen in both sexes and in both dose groups. In girls, in both dose groups, mean age at peak height velocity (PHV) and mean age at menarche occurred significantly earlier than in the normal population. In boys, there was a normal timing of PHV. The amplitude of PHV was significantly reduced in both sexes and in both dose groups. Parameters of pubertal duration (PHV to menarche, PHV to FH, and menarche to FH) were not significantly different from normal population values. CONCLUSION: In conclusion, puberty occurred early in girls, but not in boys. Amplitude of PHV was reduced in both sexes, with no reduction in the duration of puberty. It is likely that disturbances of both timing and quality of growth during puberty contribute to the loss of standing height and body disproportion seen in these children.
    Citation
    Pubertal growth in young adult survivors of childhood leukemia. 1995, 13 (10):2503-7 J. Clin. Oncol.
    Journal
    Journal of Clinical Oncology
    URI
    http://hdl.handle.net/10541/97213
    DOI
    10.1002/mpo.2950220407
    PubMed ID
    7595700
    Type
    Article
    Language
    en
    ISSN
    0732-183X
    ae974a485f413a2113503eed53cd6c53
    10.1002/mpo.2950220407
    Scopus Count
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