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dc.contributor.authorHartley, Ann L
dc.contributor.authorBirch, Jillian M
dc.contributor.authorHarris, Martin
dc.contributor.authorBlair, Val
dc.contributor.authorMorris Jones, P H
dc.contributor.authorGattamaneni, Rao
dc.contributor.authorKelsey, Anna M
dc.date.accessioned2010-04-22T10:28:33Z
dc.date.available2010-04-22T10:28:33Z
dc.date.issued1994-10-15
dc.identifier.citationLeukemia, lymphoma, and related disorders in families of children diagnosed with Wilms' tumor. 1994, 77 (2):129-33 Cancer Genet. Cytogenet.en
dc.identifier.issn0165-4608
dc.identifier.pmid7954323
dc.identifier.doi10.1016/0165-4608(94)90228-3
dc.identifier.urihttp://hdl.handle.net/10541/97153
dc.description.abstractLeukemias and lymphomas occurring in a series of families with Wilms' tumor (WT) are described. One surviving case developed a large cell anaplastic Ki-1 lymphoma at age 20 years, and 23 second- and higher degree relatives were affected. In two instances leukemia/lymphoma occurred in the context of Li-Fraumeni syndrome (LFS) and two other families showed striking clusters of unusual and early-onset malignancies. In several cases, children had genitourinary abnormalities of the type associated with the WT1 gene on chromosome 11p13. Some of these families may provide important subjects for study of WT genes in hematologic disease and lymphomas and for investigation of interaction between different tumor-suppressor genes, e.g., WT1 and other candidate WT genes, and p53.
dc.language.isoenen
dc.subjectKidney Canceren
dc.subjectLeukaemiaen
dc.subjectWilms Tumouren
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshKidney Neoplasms
dc.subject.meshLeukemia
dc.subject.meshLymphoma
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPedigree
dc.subject.meshWilms Tumor
dc.titleLeukemia, lymphoma, and related disorders in families of children diagnosed with Wilms' tumor.en
dc.typeArticleen
dc.contributor.departmentCRC Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, England.en
dc.identifier.journalCancer Genetics and Cytogeneticsen
html.description.abstractLeukemias and lymphomas occurring in a series of families with Wilms' tumor (WT) are described. One surviving case developed a large cell anaplastic Ki-1 lymphoma at age 20 years, and 23 second- and higher degree relatives were affected. In two instances leukemia/lymphoma occurred in the context of Li-Fraumeni syndrome (LFS) and two other families showed striking clusters of unusual and early-onset malignancies. In several cases, children had genitourinary abnormalities of the type associated with the WT1 gene on chromosome 11p13. Some of these families may provide important subjects for study of WT genes in hematologic disease and lymphomas and for investigation of interaction between different tumor-suppressor genes, e.g., WT1 and other candidate WT genes, and p53.


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