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    Leukemia, lymphoma, and related disorders in families of children diagnosed with Wilms' tumor.

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    Authors
    Hartley, Ann L
    Birch, Jillian M
    Harris, Martin
    Blair, Val
    Morris Jones, P H
    Gattamaneni, Rao
    Kelsey, Anna M
    Affiliation
    CRC Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, England.
    Issue Date
    1994-10-15
    
    Metadata
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    Abstract
    Leukemias and lymphomas occurring in a series of families with Wilms' tumor (WT) are described. One surviving case developed a large cell anaplastic Ki-1 lymphoma at age 20 years, and 23 second- and higher degree relatives were affected. In two instances leukemia/lymphoma occurred in the context of Li-Fraumeni syndrome (LFS) and two other families showed striking clusters of unusual and early-onset malignancies. In several cases, children had genitourinary abnormalities of the type associated with the WT1 gene on chromosome 11p13. Some of these families may provide important subjects for study of WT genes in hematologic disease and lymphomas and for investigation of interaction between different tumor-suppressor genes, e.g., WT1 and other candidate WT genes, and p53.
    Citation
    Leukemia, lymphoma, and related disorders in families of children diagnosed with Wilms' tumor. 1994, 77 (2):129-33 Cancer Genet. Cytogenet.
    Journal
    Cancer Genetics and Cytogenetics
    URI
    http://hdl.handle.net/10541/97153
    DOI
    10.1016/0165-4608(94)90228-3
    PubMed ID
    7954323
    Type
    Article
    Language
    en
    ISSN
    0165-4608
    ae974a485f413a2113503eed53cd6c53
    10.1016/0165-4608(94)90228-3
    Scopus Count
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