Phase II study of liposomal muramyl tripeptide phosphatidylethanolamine (MTP/PE) in advanced soft tissue sarcomas of the adult. An EORTC Soft Tissue and Bone Sarcoma Group study.
Authors
Verweij, JJudson, I
Steward, William P
Coleman, R
Woll, Penella J
Van Pottelsberghe, C
Van Glabbeke, Martine M
Mouridsen, H
Affiliation
Department of Medical Oncology, Rotterdam Cancer Institute, The Netherlands.Issue Date
1994
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The EORTC Soft Tissue and Bone Sarcoma Group conducted a phase II study with intravenous muramyl tripeptide phosphatidylethanolamine (MTP/PE) at a dose of 4 mg once weekly in 20 patients with metastatic soft tissue sarcomas. Responses were not seen in 19 evaluable patients. Toxicity consisted mainly of a mild flu-like syndrome after 62% of drug administrations. It is concluded that MTP/PE at this dose and schedule has no activity in metastatic soft tissue sarcoma.Citation
Phase II study of liposomal muramyl tripeptide phosphatidylethanolamine (MTP/PE) in advanced soft tissue sarcomas of the adult. An EORTC Soft Tissue and Bone Sarcoma Group study. 1994, 30A (6):842-3 Eur. J. CancerJournal
European Journal of CancerDOI
10.1016/0959-8049(94)90303-4PubMed ID
7917546Type
ArticleLanguage
enISSN
0959-8049ae974a485f413a2113503eed53cd6c53
10.1016/0959-8049(94)90303-4
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