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dc.contributor.authorHartley, Ann L
dc.contributor.authorBirch, Jillian M
dc.contributor.authorBlair, Val
dc.contributor.authorKelsey, Anna M
dc.date.accessioned2010-04-22T09:48:49Z
dc.date.available2010-04-22T09:48:49Z
dc.date.issued1994-10
dc.identifier.citationMalformations in children with soft tissue sarcoma and in their parents and siblings. 1994, 8 (4):423-32 Paediatr Perinat Epidemiolen
dc.identifier.issn0269-5022
dc.identifier.pmid7870626
dc.identifier.doi10.1111/j.1365-3016.1994.tb00481.x
dc.identifier.urihttp://hdl.handle.net/10541/97140
dc.description.abstractThe presence of malformations in a population-based series of 181 children diagnosed with soft tissue sarcoma and in the majority of their parents and siblings was ascertained from family interviews and medical records. Five index children (2.8%) had serious anomalies, a figure not in excess of that derived from general population data. Fourteen siblings (4%) were affected, and higher rates of malformations were seen in siblings of female case children (P = 0.06) and siblings of children with visceral tumours (P = 0.03). There was no correlation between site of tumour in the index and specific organ system anomalies in the index or in their respective siblings. The survey indicated that there are unlikely to be strong associations between childhood soft tissue sarcoma and major malformations, a situation distinct from that found in Wilms' tumour.
dc.language.isoenen
dc.subject.meshAdolescent
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshCongenital Abnormalities
dc.subject.meshEngland
dc.subject.meshFamily Health
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIncidence
dc.subject.meshInfant
dc.subject.meshMale
dc.subject.meshSarcoma
dc.subject.meshSeverity of Illness Index
dc.titleMalformations in children with soft tissue sarcoma and in their parents and siblings.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Paediatric and Familial Cancer Research Group, Christie Hospital, Manchester, UK.en
dc.identifier.journalPaediatric and Perinatal Epidemiologyen
html.description.abstractThe presence of malformations in a population-based series of 181 children diagnosed with soft tissue sarcoma and in the majority of their parents and siblings was ascertained from family interviews and medical records. Five index children (2.8%) had serious anomalies, a figure not in excess of that derived from general population data. Fourteen siblings (4%) were affected, and higher rates of malformations were seen in siblings of female case children (P = 0.06) and siblings of children with visceral tumours (P = 0.03). There was no correlation between site of tumour in the index and specific organ system anomalies in the index or in their respective siblings. The survey indicated that there are unlikely to be strong associations between childhood soft tissue sarcoma and major malformations, a situation distinct from that found in Wilms' tumour.


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