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    Malformations in children with soft tissue sarcoma and in their parents and siblings.

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    Authors
    Hartley, Ann L
    Birch, Jillian M
    Blair, Val
    Kelsey, Anna M
    Affiliation
    Cancer Research Campaign Paediatric and Familial Cancer Research Group, Christie Hospital, Manchester, UK.
    Issue Date
    1994-10
    
    Metadata
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    Abstract
    The presence of malformations in a population-based series of 181 children diagnosed with soft tissue sarcoma and in the majority of their parents and siblings was ascertained from family interviews and medical records. Five index children (2.8%) had serious anomalies, a figure not in excess of that derived from general population data. Fourteen siblings (4%) were affected, and higher rates of malformations were seen in siblings of female case children (P = 0.06) and siblings of children with visceral tumours (P = 0.03). There was no correlation between site of tumour in the index and specific organ system anomalies in the index or in their respective siblings. The survey indicated that there are unlikely to be strong associations between childhood soft tissue sarcoma and major malformations, a situation distinct from that found in Wilms' tumour.
    Citation
    Malformations in children with soft tissue sarcoma and in their parents and siblings. 1994, 8 (4):423-32 Paediatr Perinat Epidemiol
    Journal
    Paediatric and Perinatal Epidemiology
    URI
    http://hdl.handle.net/10541/97140
    DOI
    10.1111/j.1365-3016.1994.tb00481.x
    PubMed ID
    7870626
    Type
    Article
    Language
    en
    ISSN
    0269-5022
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-3016.1994.tb00481.x
    Scopus Count
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