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dc.contributor.authorYamazaki, K
dc.contributor.authorEyden, Brian P
dc.date.accessioned2010-04-22T09:39:11Z
dc.date.available2010-04-22T09:39:11Z
dc.date.issued1994-10
dc.identifier.citationLipid-rich residual bodies in the human thyroid gland: ultrastructural, histochemical, and morphometric study. 1994, 26 (4):553-63 J. Submicrosc. Cytol. Pathol.en
dc.identifier.issn1122-9497
dc.identifier.pmid7820818
dc.identifier.urihttp://hdl.handle.net/10541/97136
dc.description.abstractEleven samples of surgical and autopsy thyroid tissue were studied by classical histology, histochemistry, immunohistochemistry, light microscope quantitation and transmission electron microscopy in order to characterize lipid-rich residual bodies (LRRBs) previously reported in human myometrium. The following observations were made: 1) LRRBs were found largely in follicular epithelial cells; 2) they had exactly the same histochemical, immunohistochemical and ultrastructural characteristics as LRRBs from myometrium; 3) they had a distinctive distribution and morphology compared with lipofuscin; 4) a lysosomal nature was confirmed by their content of acid phosphatase and cathepsin D; 5) they were virtually absent from both the new-born thyroid and from thyroid carcinoma; 6) there was a statistical linear correlation between LRRB frequency and patient age. In conclusion, LRRBs have been demonstrated in an extra-uterine location, and are confirmed as residual lysosomes, probably having been involved in lipid metabolism.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAging
dc.subject.meshCathepsin D
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfant, Newborn
dc.subject.meshLipid Metabolism
dc.subject.meshLipofuscin
dc.subject.meshLysosomes
dc.subject.meshMale
dc.subject.meshMicroscopy, Electron
dc.subject.meshMiddle Aged
dc.subject.meshPhosphoric Monoester Hydrolases
dc.subject.meshThyroid Gland
dc.titleLipid-rich residual bodies in the human thyroid gland: ultrastructural, histochemical, and morphometric study.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, School of Medicine Keio University, Tokyo, Japan.en
dc.identifier.journalJournal of Submicroscopic Cytology and Pathologyen
html.description.abstractEleven samples of surgical and autopsy thyroid tissue were studied by classical histology, histochemistry, immunohistochemistry, light microscope quantitation and transmission electron microscopy in order to characterize lipid-rich residual bodies (LRRBs) previously reported in human myometrium. The following observations were made: 1) LRRBs were found largely in follicular epithelial cells; 2) they had exactly the same histochemical, immunohistochemical and ultrastructural characteristics as LRRBs from myometrium; 3) they had a distinctive distribution and morphology compared with lipofuscin; 4) a lysosomal nature was confirmed by their content of acid phosphatase and cathepsin D; 5) they were virtually absent from both the new-born thyroid and from thyroid carcinoma; 6) there was a statistical linear correlation between LRRB frequency and patient age. In conclusion, LRRBs have been demonstrated in an extra-uterine location, and are confirmed as residual lysosomes, probably having been involved in lipid metabolism.


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