Lipid-rich residual bodies in the human thyroid gland: ultrastructural, histochemical, and morphometric study.
dc.contributor.author | Yamazaki, K | |
dc.contributor.author | Eyden, Brian P | |
dc.date.accessioned | 2010-04-22T09:39:11Z | |
dc.date.available | 2010-04-22T09:39:11Z | |
dc.date.issued | 1994-10 | |
dc.identifier.citation | Lipid-rich residual bodies in the human thyroid gland: ultrastructural, histochemical, and morphometric study. 1994, 26 (4):553-63 J. Submicrosc. Cytol. Pathol. | en |
dc.identifier.issn | 1122-9497 | |
dc.identifier.pmid | 7820818 | |
dc.identifier.uri | http://hdl.handle.net/10541/97136 | |
dc.description.abstract | Eleven samples of surgical and autopsy thyroid tissue were studied by classical histology, histochemistry, immunohistochemistry, light microscope quantitation and transmission electron microscopy in order to characterize lipid-rich residual bodies (LRRBs) previously reported in human myometrium. The following observations were made: 1) LRRBs were found largely in follicular epithelial cells; 2) they had exactly the same histochemical, immunohistochemical and ultrastructural characteristics as LRRBs from myometrium; 3) they had a distinctive distribution and morphology compared with lipofuscin; 4) a lysosomal nature was confirmed by their content of acid phosphatase and cathepsin D; 5) they were virtually absent from both the new-born thyroid and from thyroid carcinoma; 6) there was a statistical linear correlation between LRRB frequency and patient age. In conclusion, LRRBs have been demonstrated in an extra-uterine location, and are confirmed as residual lysosomes, probably having been involved in lipid metabolism. | |
dc.language.iso | en | en |
dc.subject.mesh | Adult | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Aging | |
dc.subject.mesh | Cathepsin D | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Infant, Newborn | |
dc.subject.mesh | Lipid Metabolism | |
dc.subject.mesh | Lipofuscin | |
dc.subject.mesh | Lysosomes | |
dc.subject.mesh | Male | |
dc.subject.mesh | Microscopy, Electron | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Phosphoric Monoester Hydrolases | |
dc.subject.mesh | Thyroid Gland | |
dc.title | Lipid-rich residual bodies in the human thyroid gland: ultrastructural, histochemical, and morphometric study. | en |
dc.type | Article | en |
dc.contributor.department | Department of Pathology, School of Medicine Keio University, Tokyo, Japan. | en |
dc.identifier.journal | Journal of Submicroscopic Cytology and Pathology | en |
html.description.abstract | Eleven samples of surgical and autopsy thyroid tissue were studied by classical histology, histochemistry, immunohistochemistry, light microscope quantitation and transmission electron microscopy in order to characterize lipid-rich residual bodies (LRRBs) previously reported in human myometrium. The following observations were made: 1) LRRBs were found largely in follicular epithelial cells; 2) they had exactly the same histochemical, immunohistochemical and ultrastructural characteristics as LRRBs from myometrium; 3) they had a distinctive distribution and morphology compared with lipofuscin; 4) a lysosomal nature was confirmed by their content of acid phosphatase and cathepsin D; 5) they were virtually absent from both the new-born thyroid and from thyroid carcinoma; 6) there was a statistical linear correlation between LRRB frequency and patient age. In conclusion, LRRBs have been demonstrated in an extra-uterine location, and are confirmed as residual lysosomes, probably having been involved in lipid metabolism. |