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dc.contributor.authorHartley, Ann Len
dc.contributor.authorBirch, Jillian Men
dc.contributor.authorBlair, Valen
dc.contributor.authorKelsey, Anna Men
dc.contributor.authorMorris Jones, P Hen
dc.date.accessioned2010-04-21T13:59:50Z
dc.date.available2010-04-21T13:59:50Z
dc.date.issued1994-03-01
dc.identifier.citationFoetal loss and infant deaths in families of children with soft-tissue sarcoma. 1994, 56 (5):646-9 Int. J. Canceren
dc.identifier.issn0020-7136
dc.identifier.pmid8314340
dc.identifier.doi10.1002/ijc.2910560507
dc.identifier.urihttp://hdl.handle.net/10541/97079
dc.description.abstractDistribution of miscarriages, stillbirths and infant deaths in the families of a population-based series of children with soft-tissue sarcoma was examined in relation to index case histology (rhabdomyosarcoma or other soft-tissue sarcoma) and to the possible presence of genetic predisposition to cancer in the families (Li-Fraumeni syndrome or neurofibromatosis). Reproductive loss was not related to index histology (miscarriages, p = 0.3; all losses, p = 0.6) but was significantly higher in "genetic" rather than "sporadic" families (miscarriages, p = 0.02; all losses, p = 0.01). However, excess reproductive loss was not a feature of families with the Li-Fraumeni syndrome, but appeared to be concentrated in the families affected by neurofibromatosis.
dc.language.isoenen
dc.subjectSoft Tissue Canceren
dc.subjectFoetal Deathen
dc.subject.meshAbortion, Spontaneous
dc.subject.meshAdolescent
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshDisease Susceptibility
dc.subject.meshFamily
dc.subject.meshFemale
dc.subject.meshFetal Death
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshInfant Mortality
dc.subject.meshInfant, Newborn
dc.subject.meshLi-Fraumeni Syndrome
dc.subject.meshMaternal Age
dc.subject.meshNeurofibromatoses
dc.subject.meshPregnancy
dc.subject.meshRhabdomyosarcoma
dc.subject.meshSarcoma
dc.subject.meshSoft Tissue Neoplasms
dc.titleFoetal loss and infant deaths in families of children with soft-tissue sarcoma.en
dc.typeArticleen
dc.contributor.departmentCRC Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalInternational Journal of Canceren
html.description.abstractDistribution of miscarriages, stillbirths and infant deaths in the families of a population-based series of children with soft-tissue sarcoma was examined in relation to index case histology (rhabdomyosarcoma or other soft-tissue sarcoma) and to the possible presence of genetic predisposition to cancer in the families (Li-Fraumeni syndrome or neurofibromatosis). Reproductive loss was not related to index histology (miscarriages, p = 0.3; all losses, p = 0.6) but was significantly higher in "genetic" rather than "sporadic" families (miscarriages, p = 0.02; all losses, p = 0.01). However, excess reproductive loss was not a feature of families with the Li-Fraumeni syndrome, but appeared to be concentrated in the families affected by neurofibromatosis.


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