Foetal loss and infant deaths in families of children with soft-tissue sarcoma.
Affiliation
CRC Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, UK.Issue Date
1994-03-01
Metadata
Show full item recordAbstract
Distribution of miscarriages, stillbirths and infant deaths in the families of a population-based series of children with soft-tissue sarcoma was examined in relation to index case histology (rhabdomyosarcoma or other soft-tissue sarcoma) and to the possible presence of genetic predisposition to cancer in the families (Li-Fraumeni syndrome or neurofibromatosis). Reproductive loss was not related to index histology (miscarriages, p = 0.3; all losses, p = 0.6) but was significantly higher in "genetic" rather than "sporadic" families (miscarriages, p = 0.02; all losses, p = 0.01). However, excess reproductive loss was not a feature of families with the Li-Fraumeni syndrome, but appeared to be concentrated in the families affected by neurofibromatosis.Citation
Foetal loss and infant deaths in families of children with soft-tissue sarcoma. 1994, 56 (5):646-9 Int. J. CancerJournal
International Journal of CancerDOI
10.1002/ijc.2910560507PubMed ID
8314340Type
ArticleLanguage
enISSN
0020-7136ae974a485f413a2113503eed53cd6c53
10.1002/ijc.2910560507
Scopus Count
Collections
Related articles
- Patterns of cancer in the families of children with soft tissue sarcoma.
- Authors: Hartley AL, Birch JM, Blair V, Kelsey AM, Harris M, Jones PH
- Issue date: 1993 Aug 1
- Li-Fraumeni syndrome in pediatric patients with soft tissue sarcoma or osteosarcoma.
- Authors: Carnevale A, Lieberman E, Cárdenas R
- Issue date: 1997 Autumn
- Li-Fraumeni syndrome.
- Authors: Birch JM
- Issue date: 1994
- The Li-Fraumeni syndrome: from clinical epidemiology to molecular genetics.
- Authors: Strong LC, Williams WR, Tainsky MA
- Issue date: 1992 Jan 15
- Malignant disease in the mothers of a population-based series of young adults with bone and soft tissue sarcomas.
- Authors: Hartley AL, Birch JM, Blair V
- Issue date: 1991 Mar