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    Differences in MHC and TAP-1 expression in cervical cancer lymph node metastases as compared with the primary tumours.

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    Authors
    Cromme, F V
    Walboomers, J M
    Gallee, M P
    Stern, Peter L
    Kenemans, P
    Helmerhorst, T J
    Stukart, M J
    Meijer, C J
    Affiliation
    Institute for Pathology, Free University Hospital, Amsterdam, The Netherlands.
    Issue Date
    1994-06
    
    Metadata
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    Abstract
    In previous studies we have shown down-regulation of class I major histocompatibility complex (MHC) expression in a significant proportion of primary cervical carcinomas, which was found to be strongly correlated with loss of expression of the transporter associated with antigen presentation (TAP). By contrast, class II MHC expression was frequently up-regulated on neoplastic keratinocytes in these malignancies. In order to investigate whether these changes are associated with biological behaviour of the tumours, 20 cervical carcinomas were analyzed for MHC (HLA-A, HLA-B/C, HLA-DR) and TAP-1 expression in the primary tumours and in lymph node metastases by immunohistochemistry. The results showed a significant increase in the prevalence of HLA-A and HLA-B/C down-regulation in metastasised neoplastic cells as compared with the primary tumour (P = 0.01). In all cases this was accompanied by loss of TAP-1 expression. Up-regulated HLA-DR expression was found exclusively in primary tumours and was absent in the corresponding metastases (P = 0.002). These data are consistent with the hypothesis that loss of TAP-1 and the consequent down-regulation of class I MHC expression provides a selective advantage for neoplastic cervical cells during metastasis. Furthermore, the lack of class II MHC expression in metastasised cells either reflects a different local lymphokine production or indicates that these cells may have escaped CD4+ cytotoxic T-lymphocyte (CTL)-mediated killing.
    Citation
    Differences in MHC and TAP-1 expression in cervical cancer lymph node metastases as compared with the primary tumours. 1994, 69 (6):1176-81 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/97078
    PubMed ID
    8198988
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Paterson Institute for Cancer Research

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