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dc.contributor.authorPrescott, R J
dc.contributor.authorBanerjee, Saumitra S
dc.contributor.authorEyden, Brian P
dc.contributor.authorHaboubi, N Y
dc.date.accessioned2010-04-21T13:44:18Z
dc.date.available2010-04-21T13:44:18Z
dc.date.issued1994-11
dc.identifier.citationCutaneous epithelioid angiosarcoma: a clinicopathological study of four cases. 1994, 25 (5):421-9 Histopathologyen
dc.identifier.issn0309-0167
dc.identifier.pmid7868082
dc.identifier.doi10.1111/j.1365-2559.1994.tb00003.x
dc.identifier.urihttp://hdl.handle.net/10541/97075
dc.description.abstractFour cases of cutaneous epithelioid angiosarcoma are described together with the potential diagnostic trap of mistaking these tumours for poorly differentiated carcinoma or malignant melanoma. The immunophenotypic profile using four endothelial markers showed positive staining in all cases for factor VIII related antigen in a predominantly paranuclear dot-like fashion and for CD31 (JC70); in three cases for CD34 (QB-END/10) and in two cases with UEA-1. All four cases were cytokeratin (CAM 5.2 and AE1/AE3) negative in contrast to the positive staining reported at non-cutaneous sites. Aberrant S-100 protein expression was seen in one case. In two cases subsequent recurrences showed better differentiation than the original tumour. Electronmicroscopy confirmed the absence of non-endothelial lines of differentiation but failed to reveal Weibel-Palade bodies.
dc.language.isoenen
dc.subjectSkin Canceren
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshEpithelium
dc.subject.meshFemale
dc.subject.meshHemangiosarcoma
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshSkin Neoplasms
dc.titleCutaneous epithelioid angiosarcoma: a clinicopathological study of four cases.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Bolton General Hospital, UK.en
dc.identifier.journalHistopathologyen
html.description.abstractFour cases of cutaneous epithelioid angiosarcoma are described together with the potential diagnostic trap of mistaking these tumours for poorly differentiated carcinoma or malignant melanoma. The immunophenotypic profile using four endothelial markers showed positive staining in all cases for factor VIII related antigen in a predominantly paranuclear dot-like fashion and for CD31 (JC70); in three cases for CD34 (QB-END/10) and in two cases with UEA-1. All four cases were cytokeratin (CAM 5.2 and AE1/AE3) negative in contrast to the positive staining reported at non-cutaneous sites. Aberrant S-100 protein expression was seen in one case. In two cases subsequent recurrences showed better differentiation than the original tumour. Electronmicroscopy confirmed the absence of non-endothelial lines of differentiation but failed to reveal Weibel-Palade bodies.


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