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    Cutaneous epithelioid angiosarcoma: a clinicopathological study of four cases.

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    Authors
    Prescott, R J
    Banerjee, Saumitra S
    Eyden, Brian P
    Haboubi, N Y
    Affiliation
    Department of Pathology, Bolton General Hospital, UK.
    Issue Date
    1994-11
    
    Metadata
    Show full item record
    Abstract
    Four cases of cutaneous epithelioid angiosarcoma are described together with the potential diagnostic trap of mistaking these tumours for poorly differentiated carcinoma or malignant melanoma. The immunophenotypic profile using four endothelial markers showed positive staining in all cases for factor VIII related antigen in a predominantly paranuclear dot-like fashion and for CD31 (JC70); in three cases for CD34 (QB-END/10) and in two cases with UEA-1. All four cases were cytokeratin (CAM 5.2 and AE1/AE3) negative in contrast to the positive staining reported at non-cutaneous sites. Aberrant S-100 protein expression was seen in one case. In two cases subsequent recurrences showed better differentiation than the original tumour. Electronmicroscopy confirmed the absence of non-endothelial lines of differentiation but failed to reveal Weibel-Palade bodies.
    Citation
    Cutaneous epithelioid angiosarcoma: a clinicopathological study of four cases. 1994, 25 (5):421-9 Histopathology
    Journal
    Histopathology
    URI
    http://hdl.handle.net/10541/97075
    DOI
    10.1111/j.1365-2559.1994.tb00003.x
    PubMed ID
    7868082
    Type
    Article
    Language
    en
    ISSN
    0309-0167
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2559.1994.tb00003.x
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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