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dc.contributor.authorHartley, Ann L
dc.contributor.authorBirch, Jillian M
dc.contributor.authorBlair, Val
dc.contributor.authorKelsey, Anna M
dc.contributor.authorHarris, Martin
dc.contributor.authorJones, P H
dc.contributor.authorGattamaneni, Rao
dc.date.accessioned2010-04-21T14:10:20Z
dc.date.available2010-04-21T14:10:20Z
dc.date.issued1994-01
dc.identifier.citationGenitourinary tumors in the families of children with renal tumors. 1994, 72 (1):28-32 Cancer Genet. Cytogenet.en
dc.identifier.issn0165-4608
dc.identifier.pmid8111735
dc.identifier.doi10.1016/0165-4608(94)90105-8
dc.identifier.urihttp://hdl.handle.net/10541/97063
dc.description.abstractThe occurrence of genitourinary tumors in the relatives of a population-based series of 218 children diagnosed with renal tumors was investigated. Family data on 92% (176 of 192) of Wilms' tumor (WT) patients and 77% (20 of 26) of other renal tumor patients were obtained. In all, 21 genitourinary tumors in first-degree relatives in 19 families were ascertained, together with 30 such tumors in second-degree relatives. Ten families were diagnosed with multiple genitourinary tumors, although none of these manifested familial WT. It is proposed that a small proportion of families of children with renal tumors has a genetic predisposition to develop genitourinary tumors and that these tumors may represent further manifestations of the pleiotropic effects of the WT1 gene or of other genes involved in WT predisposition.
dc.language.isoenen
dc.subjectWilms Tumouren
dc.subjectWilms Tumour Genesen
dc.subjectKidney Canceren
dc.subjectMultiple Primary Canceren
dc.subjectUrogenital Canceren
dc.subject.meshAdult
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshGenes, Wilms Tumor
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshKaryotyping
dc.subject.meshKidney Neoplasms
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasms, Multiple Primary
dc.subject.meshUrogenital Neoplasms
dc.subject.meshWilms Tumor
dc.titleGenitourinary tumors in the families of children with renal tumors.en
dc.typeArticleen
dc.contributor.departmentCRC Paediatric and Familial Cancer Research Group, Christie Hospital Trust, Manchester, England.en
dc.identifier.journalCancer Genetics and Cytogeneticsen
html.description.abstractThe occurrence of genitourinary tumors in the relatives of a population-based series of 218 children diagnosed with renal tumors was investigated. Family data on 92% (176 of 192) of Wilms' tumor (WT) patients and 77% (20 of 26) of other renal tumor patients were obtained. In all, 21 genitourinary tumors in first-degree relatives in 19 families were ascertained, together with 30 such tumors in second-degree relatives. Ten families were diagnosed with multiple genitourinary tumors, although none of these manifested familial WT. It is proposed that a small proportion of families of children with renal tumors has a genetic predisposition to develop genitourinary tumors and that these tumors may represent further manifestations of the pleiotropic effects of the WT1 gene or of other genes involved in WT predisposition.


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