Disproportionate short stature after cranial irradiation and combination chemotherapy for leukaemia.
Affiliation
University Department of Paediatrics, Children's Hospital, Sheffield.Issue Date
1994-06
Metadata
Show full item recordAbstract
The effect of combination chemotherapy and cranial irradiation on final height and body proportions was retrospectively examined in a cohort of 142 children treated for acute lymphoblastic leukaemia (ALL). Eighty four children (48 girls, 36 boys) received 24 Gy cranial irradiation and 58 (35 girls, 23 boys) 18 Gy. None had received testicular or spinal irradiation. A significant reduction in standing height SD score from diagnosis to final height was seen in all groups. Of the 109 children in whom sitting height measurements were available, 88 (81%) had relatively shorter backs than legs and in 25 (23%) this disproportion was of a marked degree. After mathematical correction for sitting height loss there was no longer a significant reduction in standing height SD score at final height in all except the 24 Gy group of girls. These data suggest that disproportion is a common finding after treatment for ALL and that, at least in some children, much if not all of the height loss seen is due to a reduction in sitting height. Possible explanations for this disproportion include a disturbance of puberty or an effect of chemotherapy on spinal growth, or both.Citation
Disproportionate short stature after cranial irradiation and combination chemotherapy for leukaemia. 1994, 70 (6):472-5 Arch. Dis. Child.Journal
Archives of Disease in ChildhoodDOI
10.1136/adc.70.6.472PubMed ID
8048814Type
ArticleLanguage
enISSN
1468-2044ae974a485f413a2113503eed53cd6c53
10.1136/adc.70.6.472
Scopus Count
Collections
Related articles
- Pubertal growth in young adult survivors of childhood leukemia.
- Authors: Didcock E, Davies HA, Didi M, Ogilvy Stuart AL, Wales JK, Shalet SM
- Issue date: 1995 Oct
- Longitudinal growth and risk factors for growth deficiency in children treated for acute lymphoblastic leukemia.
- Authors: Vilela MI, Viana MB
- Issue date: 2007 Jan
- Growth, puberty and obesity after treatment for leukaemia.
- Authors: Davies HA, Didcock E, Didi M, Ogilvy-Stuart A, Wales JK, Shalet SM
- Issue date: 1995 Sep
- Impaired pubertal growth in acute lymphoblastic leukaemia.
- Authors: Uruena M, Stanhope R, Chessells JM, Leiper AD
- Issue date: 1991 Dec
- Final height after treatment for childhood acute lymphoblastic leukemia: comparison of no cranial irradiation with 1800 and 2400 centigrays of cranial irradiation.
- Authors: Sklar C, Mertens A, Walter A, Mitchell D, Nesbit M, O'Leary M, Hutchinson R, Meadows A, Robison L
- Issue date: 1993 Jul