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    Carcinosarcoma of the ovary treated over a 10-year period at the Christie Hospital.

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    Authors
    Prendiville, Joseph A
    Murphy, D
    Renninson, J
    Buckley, H
    Crowther, Derek
    Affiliation
    CRC Department of Medical Oncology, Christie Hospital & Holt Radium Institute, Wilmslow Road,Department of Reproductive Pathology, St Mary's Hospital, Oxford Road, Manchester, UK.
    Issue Date
    1994-05
    
    Metadata
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    Abstract
    Carcinosarcomas (previously termed malignant mixed Müllerian tumors) are highly malignant but rare tumors of the ovary. Most patients have been treated according to a wide variety of protocols for soft tissue sarcoma or for epithelial ovarian carcinoma and as a result the optimal treatment for this neoplasm is unknown. We describe here 20 patients with this ovarian tumor (15 with heterologous sarcomatous elements and five with homologous sarcomatous elements) referred to our institute. Five patients were treated with surgery alone, two patients with chemotherapy alone and 13 patients with a combination of surgery and chemotherapy. A variety of chemotherapeutic regimens were used reflecting the 10-year time span it took to accrue these patients. Forty-five per cent of all patients died within 1 year of initial surgery and there was a median survival of 14 months. Two patients achieved a complete remission following treatment with 10 cycles of intravenous cyclophosphamide and are still alive at 103 and 106 months follow-up. We suggest that a chemotherapy regimen combining cyclophosphamide and a platinum analog may be useful for the management of patients with carcinosarcoma of the ovary requiring further therapy following surgery.
    Citation
    Carcinosarcoma of the ovary treated over a 10-year period at the Christie Hospital. 1994, 4 (3):200-205 Int. J. Gynecol. Cancer
    Journal
    International Journal of Gynecological Cancer
    URI
    http://hdl.handle.net/10541/97028
    DOI
    10.1046/j.1525-1438.1994.04030200.x
    PubMed ID
    11578407
    Type
    Article
    Language
    en
    ISSN
    1525-1438
    ae974a485f413a2113503eed53cd6c53
    10.1046/j.1525-1438.1994.04030200.x
    Scopus Count
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    All Paterson Institute for Cancer Research

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