Approaches to the analysis of quality of life data: experiences gained from a medical research council lung cancer working party palliative chemotherapy trial.
AffiliationCRC Psychological Medicine Group, Christie Hospital NHS Trust, Withington, Manchester, UK.
MetadataShow full item record
AbstractStandardization in the choice of quality of life (QOL) instruments and their application in randomised clinical trials have been advocated and generally accepted. However, there is now an urgent need to address the problems relating to the analysis and presentation of the data thus generated. There are intrinsic difficulties associated with QOL data, namely its multidimensional nature, attrition and missing data, and there is no consensus as to how these problems should be dealt with. This paper therefore considers these problems using interim data from a large Medical Research Council randomised trial in patients with small cell lung cancer and a poor prognosis, in which attrition and compliance are major concerns. Three possible approaches to the analysis of these data, which use different subsets of patients, are examined in detail. The strengths and weaknesses of these three methods are discussed, and examples of their use in the literature are given and compared with other reported approaches. The need for a standard definition of compliance is also emphasised, and a method of presentation suggested. The best current advice is that QOL data should be analysed in a number of different ways, and conclusions reached only when consistency is seen.
CitationApproaches to the analysis of quality of life data: experiences gained from a medical research council lung cancer working party palliative chemotherapy trial. 1994, 3 (5):339-52 Qual Life Res
JournalQuality of Life Research
- A randomised trial of three or six courses of etoposide cyclophosphamide methotrexate and vincristine or six courses of etoposide and ifosfamide in small cell lung cancer (SCLC). II: Quality of life. Medical Research Council Lung Cancer Working Party.
- Authors: Bleehen NM, Girling DJ, Machin D, Stephens RJ
- Issue date: 1993 Dec
- Depression in patients with lung cancer: prevalence and risk factors derived from quality-of-life data.
- Authors: Hopwood P, Stephens RJ
- Issue date: 2000 Feb
- Assessment of quality of life during chemotherapy.
- Authors: Gunnars B, Nygren P, Glimelius B, SBU-group. Swedish Council of Technology Assessment in Health Care.
- Issue date: 2001
- Defining and analysing symptom palliation in cancer clinical trials: a deceptively difficult exercise.
- Authors: Stephens RJ, Hopwood P, Girling DJ
- Issue date: 1999 Feb