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dc.contributor.authorNarayanan, M N
dc.contributor.authorMorgenstern, Godfrey R
dc.contributor.authorChang, James
dc.contributor.authorHarrison, Christine J
dc.contributor.authorRanson, Malcolm R
dc.contributor.authorScarffe, J Howard
dc.date.accessioned2010-04-21T10:46:45Z
dc.date.available2010-04-21T10:46:45Z
dc.date.issued1994-04
dc.identifier.citationAcute lymphoblastic leukaemia following Hodgkin's disease is associated with a good prognosis. 1994, 86 (4):867-9 Br. J. Haematol.en
dc.identifier.issn0007-1048
dc.identifier.pmid7918085
dc.identifier.urihttp://hdl.handle.net/10541/97013
dc.description.abstractAcute leukaemia, both myeloid and lymphoblastic, in patients treated for Hodgkin's disease (HD) is thought to have a poor prognosis. We report four adults who developed secondary acute lymphoblastic leukaemia (ALL) following chemoradiotherapy for HD. The chromosomal translocation t(4;11) (q21;q23) was found in two patients who received a chemotherapeutic regimen containing the DNA topoisomerase II inhibitor etoposide. Three of the four patients are alive and in unmaintained first remission at 3, 5 and 9 years from diagnosis of ALL, two following autologous bone marrow transplantation. These results suggest that ALL following HD may have a good prognosis when treated aggressively.
dc.language.isoenen
dc.subjectSecond Primary Canceren
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAdult
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols
dc.subject.meshChromosomes, Human, Pair 11
dc.subject.meshChromosomes, Human, Pair 4
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHodgkin Disease
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshNeoplasms, Second Primary
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma
dc.subject.meshPrognosis
dc.subject.meshTranslocation, Genetic
dc.titleAcute lymphoblastic leukaemia following Hodgkin's disease is associated with a good prognosis.en
dc.typeArticleen
dc.contributor.departmentDepartment of Haematology, Christie Hospital, Manchester.en
dc.identifier.journalBritish Journal of Haematologyen
html.description.abstractAcute leukaemia, both myeloid and lymphoblastic, in patients treated for Hodgkin's disease (HD) is thought to have a poor prognosis. We report four adults who developed secondary acute lymphoblastic leukaemia (ALL) following chemoradiotherapy for HD. The chromosomal translocation t(4;11) (q21;q23) was found in two patients who received a chemotherapeutic regimen containing the DNA topoisomerase II inhibitor etoposide. Three of the four patients are alive and in unmaintained first remission at 3, 5 and 9 years from diagnosis of ALL, two following autologous bone marrow transplantation. These results suggest that ALL following HD may have a good prognosis when treated aggressively.


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