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dc.contributor.authorHartley, Ann L
dc.contributor.authorBirch, Jillian M
dc.contributor.authorBlair, Val
dc.contributor.authorJones, P M
dc.contributor.authorGattamaneni, Rao
dc.contributor.authorKelsey, Anna M
dc.date.accessioned2010-04-21T10:27:59Z
dc.date.available2010-04-21T10:27:59Z
dc.date.issued1994
dc.identifier.citationSecond primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood. 1994, 22 (5):318-24 Med. Pediatr. Oncol.en
dc.identifier.issn0098-1532
dc.identifier.pmid8127255
dc.identifier.doi10.1002/mpo.2950220504
dc.identifier.urihttp://hdl.handle.net/10541/96985
dc.description.abstractEight second malignant tumours developed in a population-based series of 218 patients diagnosed with renal tumours in childhood: renal cell carcinoma of the contralateral kidney, hepatocellular carcinoma, Hodgkin's disease, and 4 basal cell and 1 squamous cell carcinomas of skin. Excess risk of developing a second malignancy (excluding skin carcinomas but including a registrable spinal neurofibroma) was 14.7 (95% CI 4.0-37.7, P = 0.0003) for Wilms' tumour patients. Cumulative incidence of second malignant neoplasms (excluding skin carcinoma) was zero at 10 years, 5.0% at 20 years, and 10.2% at 30 years. The most common second neoplasms seen were benign osseous/chondromatous tumours and 4 of the 7 Wilms' tumour patients with malignant tumours had previous or synchronous tumours of this kind. Development of bony exostoses may be a marker for those patients at particularly high risk of subsequent malignancy.
dc.language.isoenen
dc.subjectKidney Canceren
dc.subjectSecond Primary Canceren
dc.subjectWilms Tumouren
dc.subject.meshAdolescent
dc.subject.meshCarcinoma
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshHodgkin Disease
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshKidney Neoplasms
dc.subject.meshMale
dc.subject.meshNeoplasms, Second Primary
dc.subject.meshRisk
dc.subject.meshWilms Tumor
dc.titleSecond primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood.en
dc.typeArticleen
dc.contributor.departmentDepartment of Epidemiology and Social Oncology, Christie Hospital NHS Trust, Manchester, England.en
dc.identifier.journalMedical and Pediatric Oncologyen
html.description.abstractEight second malignant tumours developed in a population-based series of 218 patients diagnosed with renal tumours in childhood: renal cell carcinoma of the contralateral kidney, hepatocellular carcinoma, Hodgkin's disease, and 4 basal cell and 1 squamous cell carcinomas of skin. Excess risk of developing a second malignancy (excluding skin carcinomas but including a registrable spinal neurofibroma) was 14.7 (95% CI 4.0-37.7, P = 0.0003) for Wilms' tumour patients. Cumulative incidence of second malignant neoplasms (excluding skin carcinoma) was zero at 10 years, 5.0% at 20 years, and 10.2% at 30 years. The most common second neoplasms seen were benign osseous/chondromatous tumours and 4 of the 7 Wilms' tumour patients with malignant tumours had previous or synchronous tumours of this kind. Development of bony exostoses may be a marker for those patients at particularly high risk of subsequent malignancy.


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