Second primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood.
AffiliationDepartment of Epidemiology and Social Oncology, Christie Hospital NHS Trust, Manchester, England.
MetadataShow full item record
AbstractEight second malignant tumours developed in a population-based series of 218 patients diagnosed with renal tumours in childhood: renal cell carcinoma of the contralateral kidney, hepatocellular carcinoma, Hodgkin's disease, and 4 basal cell and 1 squamous cell carcinomas of skin. Excess risk of developing a second malignancy (excluding skin carcinomas but including a registrable spinal neurofibroma) was 14.7 (95% CI 4.0-37.7, P = 0.0003) for Wilms' tumour patients. Cumulative incidence of second malignant neoplasms (excluding skin carcinoma) was zero at 10 years, 5.0% at 20 years, and 10.2% at 30 years. The most common second neoplasms seen were benign osseous/chondromatous tumours and 4 of the 7 Wilms' tumour patients with malignant tumours had previous or synchronous tumours of this kind. Development of bony exostoses may be a marker for those patients at particularly high risk of subsequent malignancy.
CitationSecond primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood. 1994, 22 (5):318-24 Med. Pediatr. Oncol.
JournalMedical and Pediatric Oncology
- Familial papillary renal cell tumors and subsequent cancers: a nationwide epidemiological study from Sweden.
- Authors: Czene K, Hemminki K
- Issue date: 2003 Apr
- Second neoplasms after megavoltage radiation for pediatric tumors.
- Authors: Gold DG, Neglia JP, Dusenbery KE
- Issue date: 2003 May 15
- Simultaneous Wilms' tumours in monozygotic twins. Case report and review of the literature.
- Authors: Svane S
- Issue date: 1997 Jun
- High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease: report from the Late Effects Study Group.
- Authors: Bhatia S, Yasui Y, Robison LL, Birch JM, Bogue MK, Diller L, DeLaat C, Fossati-Bellani F, Morgan E, Oberlin O, Reaman G, Ruymann FB, Tersak J, Meadows AT, Late Effects Study Group.
- Issue date: 2003 Dec 1
- Second malignancies after treatment for laparotomy staged IA-IIIB Hodgkin's disease: long-term analysis of risk factors and outcome.
- Authors: Mauch PM, Kalish LA, Marcus KC, Coleman CN, Shulman LN, Krill E, Come S, Silver B, Canellos GP, Tarbell NJ
- Issue date: 1996 May 1