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    Second primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood.

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    Authors
    Hartley, Ann L
    Birch, Jillian M
    Blair, Val
    Jones, P M
    Gattamaneni, Rao
    Kelsey, Anna M
    Affiliation
    Department of Epidemiology and Social Oncology, Christie Hospital NHS Trust, Manchester, England.
    Issue Date
    1994
    
    Metadata
    Show full item record
    Abstract
    Eight second malignant tumours developed in a population-based series of 218 patients diagnosed with renal tumours in childhood: renal cell carcinoma of the contralateral kidney, hepatocellular carcinoma, Hodgkin's disease, and 4 basal cell and 1 squamous cell carcinomas of skin. Excess risk of developing a second malignancy (excluding skin carcinomas but including a registrable spinal neurofibroma) was 14.7 (95% CI 4.0-37.7, P = 0.0003) for Wilms' tumour patients. Cumulative incidence of second malignant neoplasms (excluding skin carcinoma) was zero at 10 years, 5.0% at 20 years, and 10.2% at 30 years. The most common second neoplasms seen were benign osseous/chondromatous tumours and 4 of the 7 Wilms' tumour patients with malignant tumours had previous or synchronous tumours of this kind. Development of bony exostoses may be a marker for those patients at particularly high risk of subsequent malignancy.
    Citation
    Second primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood. 1994, 22 (5):318-24 Med. Pediatr. Oncol.
    Journal
    Medical and Pediatric Oncology
    URI
    http://hdl.handle.net/10541/96985
    DOI
    10.1002/mpo.2950220504
    PubMed ID
    8127255
    Type
    Article
    Language
    en
    ISSN
    0098-1532
    ae974a485f413a2113503eed53cd6c53
    10.1002/mpo.2950220504
    Scopus Count
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