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dc.contributor.authorNewton, J Sen
dc.contributor.authorDeed, Richard Wen
dc.contributor.authorMitchell, Erika L Den
dc.contributor.authorMurphy, J Jen
dc.contributor.authorNorton, John Den
dc.date.accessioned2010-04-21T09:07:08Z
dc.date.available2010-04-21T09:07:08Z
dc.date.issued1993-11-16
dc.identifier.citationA B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein. 1993, 1216 (2):314-6 Biochim. Biophys. Actaen
dc.identifier.issn0006-3002
dc.identifier.pmid8241276
dc.identifier.urihttp://hdl.handle.net/10541/96961
dc.description.abstractWe have determined the cDNA sequence of a human B cell specific, immediate early gene, designated 1R20, which is inducible in response to several B cell activation signals. The cDNA sequence predicts a 196 amino acid open reading frame comprising numerous highly basic residues and the predicted structure contains several potential alpha helical domains together with eight consensus protein phosphorylation sites. The 1R20 gene has been localised by fluorescence in situ hybridisation to chromosome band 1q31, a region known to be implicated in the pathogenesis of haemopoietic malignancies.
dc.language.isoenen
dc.subject.meshAmino Acid Sequence
dc.subject.meshB-Lymphocytes
dc.subject.meshBase Sequence
dc.subject.meshBinding Sites
dc.subject.meshChromosomes, Human, Pair 1
dc.subject.meshConserved Sequence
dc.subject.meshDNA, Complementary
dc.subject.meshGenes, Immediate-Early
dc.subject.meshHumans
dc.subject.meshImmediate-Early Proteins
dc.subject.meshLymphoma, B-Cell
dc.subject.meshMolecular Sequence Data
dc.subject.meshPhosphoproteins
dc.subject.meshRGS Proteins
dc.titleA B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein.en
dc.typeArticleen
dc.contributor.departmentImmunology Section, Kings College London, UK.en
dc.identifier.journalBiochimica et Biophysica Actaen
html.description.abstractWe have determined the cDNA sequence of a human B cell specific, immediate early gene, designated 1R20, which is inducible in response to several B cell activation signals. The cDNA sequence predicts a 196 amino acid open reading frame comprising numerous highly basic residues and the predicted structure contains several potential alpha helical domains together with eight consensus protein phosphorylation sites. The 1R20 gene has been localised by fluorescence in situ hybridisation to chromosome band 1q31, a region known to be implicated in the pathogenesis of haemopoietic malignancies.


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