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dc.contributor.authorMillar, W T
dc.contributor.authorJen, Y M
dc.contributor.authorHendry, Jolyon H
dc.contributor.authorCanney, Peter A
dc.date.accessioned2010-04-21T09:04:07Z
dc.date.available2010-04-21T09:04:07Z
dc.date.issued1994-08
dc.identifier.citationTwo components of repair in irradiated kidney colony forming cells. 1994, 66 (2):189-96 Int. J. Radiat. Biol.en
dc.identifier.issn0955-3002
dc.identifier.pmid8089628
dc.identifier.doi10.1080/09553009414551091
dc.identifier.urihttp://hdl.handle.net/10541/96960
dc.description.abstractData describing the response of mouse kidney colony-forming cells to fractionated X-irradiation using different interfraction intervals were analysed in order to detect the presence of one or more components of repair. A two-component repair model gave a superior fit, with reference to a single-repair rate model, giving distinct repair halftimes of 0.15 (approximate 95% confidence limits: 0.0, 0.40) and 5.03 (1.23, 8.84) h. These values are the first reported for normal cells in vivo, and they are similar to values calculated for tissue responses in skin, lung and the spinal cord. The slow component of repair is important in radiotherapy, in particular regarding novel hyperfractionation regimens when interfraction intervals much less than 1 day are employed.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshKidney
dc.subject.meshKidney Diseases
dc.subject.meshMathematical Computing
dc.subject.meshMice
dc.subject.meshMice, Inbred Strains
dc.subject.meshModels, Biological
dc.subject.meshRadiation Dosage
dc.subject.meshRadiation Injuries, Experimental
dc.subject.meshRegeneration
dc.subject.meshStem Cells
dc.titleTwo components of repair in irradiated kidney colony forming cells.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiation Oncology, Beatson Laboratories, University of Glasgow, UK.en
dc.identifier.journalInternational Journal of Radiation Biologyen
html.description.abstractData describing the response of mouse kidney colony-forming cells to fractionated X-irradiation using different interfraction intervals were analysed in order to detect the presence of one or more components of repair. A two-component repair model gave a superior fit, with reference to a single-repair rate model, giving distinct repair halftimes of 0.15 (approximate 95% confidence limits: 0.0, 0.40) and 5.03 (1.23, 8.84) h. These values are the first reported for normal cells in vivo, and they are similar to values calculated for tissue responses in skin, lung and the spinal cord. The slow component of repair is important in radiotherapy, in particular regarding novel hyperfractionation regimens when interfraction intervals much less than 1 day are employed.


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