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    Two components of repair in irradiated kidney colony forming cells.

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    Authors
    Millar, W T
    Jen, Y M
    Hendry, Jolyon H
    Canney, Peter A
    Affiliation
    Department of Radiation Oncology, Beatson Laboratories, University of Glasgow, UK.
    Issue Date
    1994-08
    
    Metadata
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    Abstract
    Data describing the response of mouse kidney colony-forming cells to fractionated X-irradiation using different interfraction intervals were analysed in order to detect the presence of one or more components of repair. A two-component repair model gave a superior fit, with reference to a single-repair rate model, giving distinct repair halftimes of 0.15 (approximate 95% confidence limits: 0.0, 0.40) and 5.03 (1.23, 8.84) h. These values are the first reported for normal cells in vivo, and they are similar to values calculated for tissue responses in skin, lung and the spinal cord. The slow component of repair is important in radiotherapy, in particular regarding novel hyperfractionation regimens when interfraction intervals much less than 1 day are employed.
    Citation
    Two components of repair in irradiated kidney colony forming cells. 1994, 66 (2):189-96 Int. J. Radiat. Biol.
    Journal
    International Journal of Radiation Biology
    URI
    http://hdl.handle.net/10541/96960
    DOI
    10.1080/09553009414551091
    PubMed ID
    8089628
    Type
    Article
    Language
    en
    ISSN
    0955-3002
    ae974a485f413a2113503eed53cd6c53
    10.1080/09553009414551091
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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