Biological Response Modifiers and Normal Tissue Injury After Irradiation.
AuthorsHendry, Jolyon H
AffiliationThe Cancer Research Campaign Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Manchester, England
MetadataShow full item record
AbstractThe reactions of tissues after irradiation can be modified using a variety of biologically based approaches. Cellular radiosensitivity can be changed using growth regulatory molecules (GRM) that have cell-cycle-mediated effects. Radiosensitivity can also be changed using prostaglandins, dose-miodifying factors of up to around 2 can be achieved. Proliferation and differentiation of precursor cells in early-reacting tissues can be promoted by GRM, producing substantial dose-modifying factors in tissues (eg, up to around 2 for marrow failure). Enhanced cell migration probably also plays an important role in the response of epithelial and stromal tissue elements. Antibiotics can prevent or delay the onset of bacterial infection in susceptible tissues (eg, marrow and intestine) to allow time for tissue recovery to occur. Even in situations where injury is already developing, a choice of dietary components in the case of kidney injury or modifiers of the vasculature in general (eg, using essential fatty acids) can delay or reduce the onset of late injury. Biological response modifiers have the potential to attain an increasingly important role in the management of cancer patients receiving radiotherapy as well as in the infrequent cases of high doses received in accidents.
CitationBiological Response Modifiers and Normal Tissue Injury After Irradiation. 1994, 4 (2):123-132 Semin Radiat Oncol
JournalSeminars in Radiation Oncology
- Radioprotection: the non-steroidal anti-inflammatory drugs (NSAIDs) and prostaglandins.
- Authors: Lee TK, Stupans I
- Issue date: 2002 Nov
- Cooperation of liver cells in health and disease.
- Authors: Kmieć Z
- Issue date: 2001
- Genomic instability: potential contributions to tumour and normal tissue response, and second tumours, after radiotherapy.
- Authors: Hendry JH
- Issue date: 2001 May
- Upflow anaerobic sludge blanket reactor--a review.
- Authors: Bal AS, Dhagat NN
- Issue date: 2001 Apr
- [Tuberculosis in compromised hosts].
- Issue date: 2003 Nov