Affiliation
CRC Department of Experimental Haematology, Paterson Institute for Cancer Research, Christie (NHS Trust) Hospital, Manchester, U.K.Issue Date
1994-08-30
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Show full item recordAbstract
Our previous studies have shown that haemopoietic stem cells undergo apoptotic death as a consequence of growth factor withdrawal. In this paper we review the new data that has accumulated since this observation and compare it with older data from the 'pre-apoptotic' age. Models of erythropoiesis and granulopoiesis that incorporate apoptosis as a normal physiological process controlling homeostasis are examined. The converse to cell death is cell survival, and we describe experiments which suggest that haemopoietic growth factors can not only act as mitogenic or differentiation stimuli but also act as survival signals. We, and others, have proposed that these growth factor-induced survival signals act through the membrane bound polypeptide receptors and share common features of signal transduction with proliferative responses. Enforced expression of bcl-2 in haemopoietic stem cells is able to overcome apoptosis following the withdrawal of growth factor, and the cells commit into different lineage differentiation programmes. Such cells spontaneously differentiate without cell division, suggesting a stochastic model of haemopoiesis in which the major role of haemopoietic growth factors is to suppress apoptosis and act as mitogens. We review the evidence that the underlying causes of some haematological diseases may be associated with change in the balance between cell survival and death.Citation
Apoptosis in the haemopoietic system. 1994, 345 (1313):257-63 Philos. Trans. R. Soc. Lond., B, Biol. Sci.Journal
Philosophical Transactions of the Royal Society of London. Series B, Biological SciencesDOI
10.1098/rstb.1994.0103PubMed ID
7846123Type
ArticleLanguage
enISSN
0962-8436ae974a485f413a2113503eed53cd6c53
10.1098/rstb.1994.0103
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