The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families.
Affiliation
Cancer Research Campaign, Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, UK.Issue Date
1994-06
Metadata
Show full item recordAbstract
A method is described to investigate the inheritance of disease predisposition in cancer families. It is an extension of classic genetic linkage analysis, which enables information on loss of constitutional heterozygosity (LOCH) to be incorporated into the model. This adapted model treats LOCH data as additional observations on the disease phenotype. One of the major benefits of this approach is that isolated parent-offspring pairs are now potentially informative for linkage analysis. Examples are presented.Citation
The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families. 1994, 31 (6):448-52 J. Med. Genet.Journal
Journal of Medical GeneticsDOI
10.1136/jmg.31.6.448PubMed ID
8071970Type
ArticleLanguage
enISSN
0022-2593ae974a485f413a2113503eed53cd6c53
10.1136/jmg.31.6.448
Scopus Count
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