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    Delayed-type hypersensitivity response to human papillomavirus type 16 E6 protein in a mouse model.

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    Authors
    Chambers, M A
    Stacey, Simon N
    Arrand, John R
    Stanley, M A
    Affiliation
    Department of Pathology, University of Cambridge, U.K.
    Issue Date
    1994-01
    
    Metadata
    Show full item record
    Abstract
    A mouse model incorporating the epitheliotropic nature of human papillomavirus (HPV) infections has been used to study an immune response to HPV type 16 (HPV-16) E6 protein in vivo. Using a transplantation technique, a novel immortal keratinocyte cell line expressing the E6 protein has been grafted onto syngeneic mice to re-form a differentiated epithelium overlying a granulation tissue bed. By this approach the presentation of viral antigens to the immune system can be modelled in a way analogous to the natural infection. Here we report a delayed-type hypersensitivity (DTH) reaction in grafted mice challenged intradermally with a recombinant vaccinia virus expressing the HPV-16 E6 protein. The specificity of the response was confirmed by the absence of a DTH reaction to challenge with virus expressing either HPV-16 E7 or L1 protein.
    Citation
    Delayed-type hypersensitivity response to human papillomavirus type 16 E6 protein in a mouse model. 1994, 75 ( Pt 1):165-9 J. Gen. Virol.
    Journal
    The Journal of General Virology
    URI
    http://hdl.handle.net/10541/96200
    DOI
    10.1099/0022-1317-75-1-165
    PubMed ID
    7906707
    Type
    Article
    Language
    en
    ISSN
    0022-1317
    ae974a485f413a2113503eed53cd6c53
    10.1099/0022-1317-75-1-165
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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