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dc.contributor.authorStewart, James Pen
dc.contributor.authorBehm, F Gen
dc.contributor.authorArrand, John Ren
dc.contributor.authorRooney, Claire Men
dc.date.accessioned2010-04-09T13:51:11Z
dc.date.available2010-04-09T13:51:11Z
dc.date.issued1994-05-01
dc.identifier.citationDifferential expression of viral and human interleukin-10 (IL-10) by primary B cell tumors and B cell lines. 1994, 200 (2):724-32 Virologyen
dc.identifier.issn0042-6822
dc.identifier.pmid8178456
dc.identifier.doi10.1006/viro.1994.1236
dc.identifier.urihttp://hdl.handle.net/10541/96186
dc.description.abstractHuman and viral interleukin-10 (IL-10) possess growth factor activity for human B cells and may act as autocrine growth factors in B cell malignancies. To study this possibility we have measured viral (v) and human (h) IL-10 expression in EBV-positive and negative B lineage tumors and tumor cell lines. Previous studies demonstrated IL-10 expression in cell lines and now we describe the pattern of IL-10 expression in primary Burkitt's lymphoma (BL) tumor biopsies and in BL lines of defined phenotypes. vIL-10 was expressed during the lytic (productive) phase of EBV infection, but not during virus latency. Although hIL-10 was expressed in the majority of B cell lines, it was not expressed in two BL biopsy specimens. Expression of hIL-10 did not correlate with the presence of EBV, but was associated with the differentiation state of the B cell line. Thus, vIL-10 may enhance the persistence of B cells infected at sites of virus replication, and while hIL-10 may be a factor in the growth both in vivo and in vitro of some BLs and EBV-transformed B cells, it is not an absolute requirement.
dc.language.isoenen
dc.subject.meshB-Lymphocytes
dc.subject.meshBase Sequence
dc.subject.meshBiopsy
dc.subject.meshBurkitt Lymphoma
dc.subject.meshCell Differentiation
dc.subject.meshCell Line
dc.subject.meshDNA Probes
dc.subject.meshHerpesvirus 4, Human
dc.subject.meshHumans
dc.subject.meshInterleukin-10
dc.subject.meshModels, Biological
dc.subject.meshMolecular Sequence Data
dc.subject.meshViral Proteins
dc.subject.meshVirus Latency
dc.titleDifferential expression of viral and human interleukin-10 (IL-10) by primary B cell tumors and B cell lines.en
dc.typeArticleen
dc.contributor.departmentDepartment of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101-0318.en
dc.identifier.journalVirologyen
html.description.abstractHuman and viral interleukin-10 (IL-10) possess growth factor activity for human B cells and may act as autocrine growth factors in B cell malignancies. To study this possibility we have measured viral (v) and human (h) IL-10 expression in EBV-positive and negative B lineage tumors and tumor cell lines. Previous studies demonstrated IL-10 expression in cell lines and now we describe the pattern of IL-10 expression in primary Burkitt's lymphoma (BL) tumor biopsies and in BL lines of defined phenotypes. vIL-10 was expressed during the lytic (productive) phase of EBV infection, but not during virus latency. Although hIL-10 was expressed in the majority of B cell lines, it was not expressed in two BL biopsy specimens. Expression of hIL-10 did not correlate with the presence of EBV, but was associated with the differentiation state of the B cell line. Thus, vIL-10 may enhance the persistence of B cells infected at sites of virus replication, and while hIL-10 may be a factor in the growth both in vivo and in vitro of some BLs and EBV-transformed B cells, it is not an absolute requirement.


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