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    Growth factors and the molecular control of haematopoiesis.

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    Authors
    Dexter, T Michael
    Heyworth, Clare M
    Affiliation
    Department of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital, Withington, Manchester, UK.
    Issue Date
    1994
    
    Metadata
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    Abstract
    In the absence of appropriate growth factors, for example interleukin-3 or GM-CSF, cultured bone marrow stem cells die by a process known as apoptosis or programmed cell death. Apoptosis may occur in vivo when concentrations of specific growth factors are limiting and may be a means of regulating cell numbers. Growth factors are also essential for proliferation of bone marrow stem cells but differentiation can occur, provided there is a survival stimulus in the absence of growth factors. Combinations of growth factors may be synergistic in stimulating the survival and proliferation of multipotent stem cells. Although neither stem cell factor, nor GM-CSF alone can significantly induce the proliferation of stem cells, the combination induces the proliferation of these cells. Committed progenitor cells such as granulocyte-macrophage colony-forming cells, however, are stimulated to proliferate by GM-CSF alone, while stem cell factor in combination with GM-CSF results in only a slight additive effect. To date, most research has concentrated on the growth stimulatory factors. GM-CSF has an important role in the reversal of chemotherapy-induced myelosuppression in cancer patients and in other bone marrow disorders. A number of growth inhibitory molecules have now been identified, such as macrophage inhibitory protein-1 alpha. In the future, it is possible that improvements in cure rates may be achieved in cancer patients by combining the growth inhibitory factors with the stimulatory factors. Inhibitory factors may be given before chemotherapy to prevent toxicity and stimulatory factors may be given afterwards to treat neutropenic patients.
    Citation
    Growth factors and the molecular control of haematopoiesis. 1994, 13 Suppl 2:S3-8 Eur. J. Clin. Microbiol. Infect. Dis.
    Journal
    'European Journal of Clinical Microbiology & Infectious Diseases
    URI
    http://hdl.handle.net/10541/96142
    DOI
    10.1007/BF01973595
    PubMed ID
    7875150
    Type
    Article
    Language
    en
    ISSN
    0934-9723
    ae974a485f413a2113503eed53cd6c53
    10.1007/BF01973595
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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