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    Heparan sulphates as membrane receptors for the fibroblast growth factors.

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    Authors
    Gallagher, John T
    Affiliation
    Med. Oncology Department, University of Manchester, Christie Hospital, United Kingdom.
    Issue Date
    1994-04
    
    Metadata
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    Abstract
    The complex polymeric structure of heparan sulphate contains intra-chain sequences of sulphated sugar residues that define active sites for the binding and activation of growth factors. The molecular mechanisms of recognition and activation are slowly being revealed at least in the case of the interaction of heparan sulphate with basic fibroblast growth factor. Current data indicate that relatively long but specific binding sequences in heparan sulphate may induce a conformational change in basic fibroblast growth factor exposing a site on the protein that is recognised by signal transducing receptors. Heparan sulphate may also subserve functions of dimerisation of basic fibroblast growth factor and facilitation of receptor transfer by a secondary interaction with the receptor itself. Various models for heparan sulphate mediated induction of mitogenesis by basic fibroblast growth factor have been proposed and there are suggestions that the core protein of plasma membrane heparan sulphate-proteoglycans may participate in the cell signalling process. The vital importance of heparan sulphate in controlling growth factor activities has opened up a new chapter in proteoglycan research and has brought proteoglycans into the mainstream of cell biology. Further investigation of their mode of action is likely to reveal new information on the control of cell growth and development in both embryonic and adult tissues and may suggest novel methods of controlling diseases such as cancer, atherosclerosis or fibrosis that are driven by abnormal expression of growth factors or their receptors.
    Citation
    Heparan sulphates as membrane receptors for the fibroblast growth factors. 1994, 32 (4):239-47 Eur J Clin Chem Clin Biochem
    Journal
    European Journal of Clinical Chemistry and Clinical Biochemistry
    URI
    http://hdl.handle.net/10541/96127
    PubMed ID
    8038264
    Type
    Article
    Language
    en
    ISSN
    0939-4974
    Collections
    All Paterson Institute for Cancer Research

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