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    Immunization of cottontop tamarins and rabbits with a candidate vaccine against the Epstein-Barr virus based on the major viral envelope glycoprotein gp340 and alum.

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    Authors
    Finerty, S
    Mackett, Mike
    Arrand, John R
    Watkins, P E
    Tarlton, J
    Morgan, A J
    Affiliation
    Department of Pathology, School of Medical Sciences, University of Bristol, UK.
    Issue Date
    1994-10
    
    Metadata
    Show full item record
    Abstract
    The Epstein-Barr virus (EBV) is associated with a range of life-threatening diseases in humans. Development of an effective vaccine has therefore been an important objective. One problem in the development of a subunit vaccine for human administration is the selection of a satisfactory adjuvant since the only one currently licensed for human use is alum, although this is not considered to be very effective. The present study demonstrated that a subunit vaccine composed of the EBV envelope glycoprotein gp340 with alum as the adjuvant did elicit protective immunity against EBV-induced lymphoma in three out of five cottontop tamarins. Furthermore, rabbits immunized with gp340/alum developed the same range of antibody responses as rabbits immunized with gp340/SAF-1, an experimental adjuvant claimed to be more effective than alum. Therefore, these results indicate that alum should be evaluated as an adjuvant as part of a human trial of a gp340-based subunit vaccine.
    Citation
    Immunization of cottontop tamarins and rabbits with a candidate vaccine against the Epstein-Barr virus based on the major viral envelope glycoprotein gp340 and alum. 1994, 12 (13):1180-4 Vaccine
    Journal
    Vaccine
    URI
    http://hdl.handle.net/10541/96126
    DOI
    10.1016/0264-410X(94)90240-2
    PubMed ID
    7839721
    Type
    Article
    Language
    en
    ISSN
    0264-410X
    ae974a485f413a2113503eed53cd6c53
    10.1016/0264-410X(94)90240-2
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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