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dc.contributor.authorHadfield, John A
dc.contributor.authorPavlidis, V H
dc.contributor.authorMcGown, Alan T
dc.contributor.authorWhitworth, C
dc.contributor.authorPerry, P J
dc.contributor.authorFox, Brian W
dc.date.accessioned2010-04-09T09:04:41Z
dc.date.available2010-04-09T09:04:41Z
dc.date.issued1994-10
dc.identifier.citationStructure-activity studies on 2-aryl-4H-3,1-benzoxazin-4-ones. 1994, 5 (5):533-8 Anticancer Drugsen
dc.identifier.issn0959-4973
dc.identifier.pmid7858285
dc.identifier.urihttp://hdl.handle.net/10541/96104
dc.description.abstractEight benzoxazin-4-ones related in structure to NSC 341964 (1) have been tested for cytotoxicity in two different cell systems. Two of the benzoxazin-4-ones (3 and 10) showed good cytotoxicity (ID50 = 9.9 and 8.9 microM) in P388 cells. The nitrobenzoxazin-4-one (10) caused a significant alteration in cell cycle distribution when administered to P388 cells and was an inhibitor of porcine pancreatic elastase. Structure-activity relationships are discussed.
dc.language.isoenen
dc.subjectCancer DNAen
dc.subjectAntitumour Drug Screening Assaysen
dc.subjectLeukaemia P388en
dc.subjectCultured Tumour Cellsen
dc.subject.meshAnimals
dc.subject.meshAntineoplastic Agents
dc.subject.meshDNA, Neoplasm
dc.subject.meshDrug Screening Assays, Antitumor
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshKB Cells
dc.subject.meshLeukemia P388
dc.subject.meshMagnetic Resonance Spectroscopy
dc.subject.meshMice
dc.subject.meshMice, Inbred DBA
dc.subject.meshModels, Molecular
dc.subject.meshOxazines
dc.subject.meshPancreatic Elastase
dc.subject.meshStructure-Activity Relationship
dc.subject.meshSwine
dc.subject.meshTetrazolium Salts
dc.subject.meshThiazoles
dc.subject.meshTumor Cells, Cultured
dc.titleStructure-activity studies on 2-aryl-4H-3,1-benzoxazin-4-ones.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.en
dc.identifier.journalAnti-Cancer Drugsen
html.description.abstractEight benzoxazin-4-ones related in structure to NSC 341964 (1) have been tested for cytotoxicity in two different cell systems. Two of the benzoxazin-4-ones (3 and 10) showed good cytotoxicity (ID50 = 9.9 and 8.9 microM) in P388 cells. The nitrobenzoxazin-4-one (10) caused a significant alteration in cell cycle distribution when administered to P388 cells and was an inhibitor of porcine pancreatic elastase. Structure-activity relationships are discussed.


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