Structure-activity studies on 2-aryl-4H-3,1-benzoxazin-4-ones.
dc.contributor.author | Hadfield, John A | |
dc.contributor.author | Pavlidis, V H | |
dc.contributor.author | McGown, Alan T | |
dc.contributor.author | Whitworth, C | |
dc.contributor.author | Perry, P J | |
dc.contributor.author | Fox, Brian W | |
dc.date.accessioned | 2010-04-09T09:04:41Z | |
dc.date.available | 2010-04-09T09:04:41Z | |
dc.date.issued | 1994-10 | |
dc.identifier.citation | Structure-activity studies on 2-aryl-4H-3,1-benzoxazin-4-ones. 1994, 5 (5):533-8 Anticancer Drugs | en |
dc.identifier.issn | 0959-4973 | |
dc.identifier.pmid | 7858285 | |
dc.identifier.uri | http://hdl.handle.net/10541/96104 | |
dc.description.abstract | Eight benzoxazin-4-ones related in structure to NSC 341964 (1) have been tested for cytotoxicity in two different cell systems. Two of the benzoxazin-4-ones (3 and 10) showed good cytotoxicity (ID50 = 9.9 and 8.9 microM) in P388 cells. The nitrobenzoxazin-4-one (10) caused a significant alteration in cell cycle distribution when administered to P388 cells and was an inhibitor of porcine pancreatic elastase. Structure-activity relationships are discussed. | |
dc.language.iso | en | en |
dc.subject | Cancer DNA | en |
dc.subject | Antitumour Drug Screening Assays | en |
dc.subject | Leukaemia P388 | en |
dc.subject | Cultured Tumour Cells | en |
dc.subject.mesh | Animals | |
dc.subject.mesh | Antineoplastic Agents | |
dc.subject.mesh | DNA, Neoplasm | |
dc.subject.mesh | Drug Screening Assays, Antitumor | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | KB Cells | |
dc.subject.mesh | Leukemia P388 | |
dc.subject.mesh | Magnetic Resonance Spectroscopy | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Mice, Inbred DBA | |
dc.subject.mesh | Models, Molecular | |
dc.subject.mesh | Oxazines | |
dc.subject.mesh | Pancreatic Elastase | |
dc.subject.mesh | Structure-Activity Relationship | |
dc.subject.mesh | Swine | |
dc.subject.mesh | Tetrazolium Salts | |
dc.subject.mesh | Thiazoles | |
dc.subject.mesh | Tumor Cells, Cultured | |
dc.title | Structure-activity studies on 2-aryl-4H-3,1-benzoxazin-4-ones. | en |
dc.type | Article | en |
dc.contributor.department | CRC Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK. | en |
dc.identifier.journal | Anti-Cancer Drugs | en |
html.description.abstract | Eight benzoxazin-4-ones related in structure to NSC 341964 (1) have been tested for cytotoxicity in two different cell systems. Two of the benzoxazin-4-ones (3 and 10) showed good cytotoxicity (ID50 = 9.9 and 8.9 microM) in P388 cells. The nitrobenzoxazin-4-one (10) caused a significant alteration in cell cycle distribution when administered to P388 cells and was an inhibitor of porcine pancreatic elastase. Structure-activity relationships are discussed. |