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dc.contributor.authorDeed, Richard Wen
dc.contributor.authorHirose, Tohruen
dc.contributor.authorMitchell, Erika L Den
dc.contributor.authorSantibanez-Koref, Mauro Fen
dc.contributor.authorNorton, John Den
dc.date.accessioned2010-04-09T09:08:11Z
dc.date.available2010-04-09T09:08:11Z
dc.date.issued1994-12-30
dc.identifier.citationStructural organisation and chromosomal mapping of the human Id-3 gene. 1994, 151 (1-2):309-14 Geneen
dc.identifier.issn0378-1119
dc.identifier.pmid7828896
dc.identifier.doi10.1016/0378-1119(94)90676-9
dc.identifier.urihttp://hdl.handle.net/10541/96083
dc.description.abstractThe helix-loop-helix (HLH) family of transcription factors plays a central role in the regulation of cell growth, differentiation and tumourigenesis. Members of the Id (inhibitor of DNA binding) class of these nuclear proteins are able to heterodimerise with and thereby antagonise the functions of other transcription factors of this family. We report here on the genomic organisation of the human Id3 (HLH 1R21/heir1) gene. Comparison with the two other mammalian Id genes, Id1 and Id2, reveals a highly conserved protein coding gene organisation consistent with evolution from a common, ancestral Id-like gene. In addition, by using a yeast artificial chromosome (YAC) clone of Id3, we have fine-scale mapped the gene to chromosome band 1p36.1 by fluorescence in situ hybridisation (FISH) and, using the same FISH technique, we have detected heterogeneity in tumour-associated 1p36 chromosome translocations.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectLung Canceren
dc.subjectCancer Proteinsen
dc.subjectCultured Tumour Cellsen
dc.subjectLeukaemiaen
dc.subject.meshAdenocarcinoma
dc.subject.meshAmino Acid Sequence
dc.subject.meshAnimals
dc.subject.meshBase Sequence
dc.subject.meshBreast Neoplasms
dc.subject.meshChromosome Aberrations
dc.subject.meshChromosome Mapping
dc.subject.meshChromosomes, Human, Pair 1
dc.subject.meshConsensus Sequence
dc.subject.meshConserved Sequence
dc.subject.meshEvolution
dc.subject.meshHelix-Loop-Helix Motifs
dc.subject.meshHumans
dc.subject.meshIn Situ Hybridization, Fluorescence
dc.subject.meshInhibitor of Differentiation Proteins
dc.subject.meshLeukemia
dc.subject.meshLung Neoplasms
dc.subject.meshLymphocytes
dc.subject.meshMammals
dc.subject.meshMolecular Sequence Data
dc.subject.meshNeoplasm Proteins
dc.subject.meshRestriction Mapping
dc.subject.meshSequence Homology, Amino Acid
dc.subject.meshTranscription Factors
dc.subject.meshTranslocation, Genetic
dc.subject.meshTumor Cells, Cultured
dc.titleStructural organisation and chromosomal mapping of the human Id-3 gene.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Gene Regulation, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalGeneen
html.description.abstractThe helix-loop-helix (HLH) family of transcription factors plays a central role in the regulation of cell growth, differentiation and tumourigenesis. Members of the Id (inhibitor of DNA binding) class of these nuclear proteins are able to heterodimerise with and thereby antagonise the functions of other transcription factors of this family. We report here on the genomic organisation of the human Id3 (HLH 1R21/heir1) gene. Comparison with the two other mammalian Id genes, Id1 and Id2, reveals a highly conserved protein coding gene organisation consistent with evolution from a common, ancestral Id-like gene. In addition, by using a yeast artificial chromosome (YAC) clone of Id3, we have fine-scale mapped the gene to chromosome band 1p36.1 by fluorescence in situ hybridisation (FISH) and, using the same FISH technique, we have detected heterogeneity in tumour-associated 1p36 chromosome translocations.


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