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    Serum levels of the TGF-beta receptor are increased in atherosclerosis.

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    Authors
    Blann, A D
    Wang, Ji Min
    Wilson, P B
    Kumar, Shant
    Affiliation
    Department of Surgery, University Hospital of South Manchester, Nell Lane, Didsbury, Manchester M20 8LR, UK.
    Issue Date
    1996-02
    
    Metadata
    Show full item record
    Abstract
    Murine monoclonal antibody E9 recognises a transforming growth factor (TGF) beta receptor, which is expressed in increased amounts by activated endothelial cells. In order to examine the biological role of this molecule in atherosclerosis, we have measured levels of the TGF-beta receptor alongside those of two other endothelial cell products (von Willebrand factor and soluble E-selectin) in the serum of 55 patients with atherosclerosis (29 with ischaemic heart disease and 26 with peripheral vascular disease), and in a cohort of 26 age- and sex-matched asymptomatic controls. There were increased levels of the TGF-beta receptor (P = 0.0079) and von Willebrand factor (P = 0.0001), but not soluble E-selection in patients' serum relative to the controls. In multivariate analysis of the endothelial cell products against total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressures, age, sex and smoking, both the TGF-beta receptor and von Willebrand factor correlated with total cholesterol (Spearman's r = 0.37 and r = 0.35, respectively, both P < 0.001). Lack of a correlation with a coarse endothelial damage marker von Willebrand factor or soluble E-selectin (produced by immunologically stimulated endothelial cells) implies other mechanisms are responsible for increased levels of the TGF-beta receptor in serum of patients with atherosclerosis.
    Citation
    Serum levels of the TGF-beta receptor are increased in atherosclerosis. 1996, 120 (1-2):221-6 Atherosclerosis
    Journal
    Atherosclerosis
    URI
    http://hdl.handle.net/10541/96015
    DOI
    10.1016/0021-9150(95)05713-7
    PubMed ID
    8645363
    Type
    Article
    Language
    en
    ISSN
    0021-9150
    ae974a485f413a2113503eed53cd6c53
    10.1016/0021-9150(95)05713-7
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