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    Prognostic factors for breast recurrence after conservative breast surgery and radiotherapy: results from a randomised trial.

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    Authors
    Magee, Brian
    Swindell, Ric
    Harris, Martin
    Banerjee, Saumitra S
    Affiliation
    Christie Hospital, Manchester, UK.
    Issue Date
    1996-06
    
    Metadata
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    Abstract
    Prognostic factors predicting for breast recurrence following breast conserving surgery and radiotherapy have been identified in a prospective randomised trial comparing two different radiotherapy techniques. The first used megavoltage radiation to encompass the whole breast and regional nodes (WF group). The second used an electron field directed to the tumour bed only (LF group). With a median follow up of 8 years survival in both groups was the same (72%). There was an increased rate of breast recurrence in the LF group: 25%, compared to the WF group: 13% (P = 0.00008), expressed in actuarial terms at 8 years. In a multivariate analysis of factors predicting for breast recurrence, once the difference in treatment technique is allowed for, only two factors were found to be significant: histological grade (P = 0.013) and lymphovascular invasion in the histological specimen (P = 0.037).
    Citation
    Prognostic factors for breast recurrence after conservative breast surgery and radiotherapy: results from a randomised trial. 1996, 39 (3):223-7 Radiother Oncol
    Journal
    Radiotherapy and Oncology
    URI
    http://hdl.handle.net/10541/95987
    DOI
    10.1016/0167-8140(96)01747-1
    PubMed ID
    8783398
    Type
    Article
    Language
    en
    ISSN
    0167-8140
    ae974a485f413a2113503eed53cd6c53
    10.1016/0167-8140(96)01747-1
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