Prognostic factors for breast recurrence after conservative breast surgery and radiotherapy: results from a randomised trial.
Abstract
Prognostic factors predicting for breast recurrence following breast conserving surgery and radiotherapy have been identified in a prospective randomised trial comparing two different radiotherapy techniques. The first used megavoltage radiation to encompass the whole breast and regional nodes (WF group). The second used an electron field directed to the tumour bed only (LF group). With a median follow up of 8 years survival in both groups was the same (72%). There was an increased rate of breast recurrence in the LF group: 25%, compared to the WF group: 13% (P = 0.00008), expressed in actuarial terms at 8 years. In a multivariate analysis of factors predicting for breast recurrence, once the difference in treatment technique is allowed for, only two factors were found to be significant: histological grade (P = 0.013) and lymphovascular invasion in the histological specimen (P = 0.037).Citation
Prognostic factors for breast recurrence after conservative breast surgery and radiotherapy: results from a randomised trial. 1996, 39 (3):223-7 Radiother OncolJournal
Radiotherapy and OncologyDOI
10.1016/0167-8140(96)01747-1PubMed ID
8783398Type
ArticleLanguage
enISSN
0167-8140ae974a485f413a2113503eed53cd6c53
10.1016/0167-8140(96)01747-1
Scopus Count
Collections
Related articles
- [Local relapse in young (< or = 40 years) women with breast cancer after mastectomy or breast conserving surgery: 15-year results].
- Authors: Fodor J, Mózsa E, Zaka Z, Polgár C, Major T
- Issue date: 2005
- Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial.
- Authors: Kunkler IH, Williams LJ, Jack WJ, Cameron DA, Dixon JM, PRIME II investigators
- Issue date: 2015 Mar
- The Christie Hospital breast conservation trial: an update at 8 years from inception.
- Authors: Ribeiro GG, Magee B, Swindell R, Harris M, Banerjee SS
- Issue date: 1993
- Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial.
- Authors: Veronesi U, Orecchia R, Maisonneuve P, Viale G, Rotmensz N, Sangalli C, Luini A, Veronesi P, Galimberti V, Zurrida S, Leonardi MC, Lazzari R, Cattani F, Gentilini O, Intra M, Caldarella P, Ballardini B
- Issue date: 2013 Dec
- Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial.
- Authors: Vaidya JS, Joseph DJ, Tobias JS, Bulsara M, Wenz F, Saunders C, Alvarado M, Flyger HL, Massarut S, Eiermann W, Keshtgar M, Dewar J, Kraus-Tiefenbacher U, Sütterlin M, Esserman L, Holtveg HM, Roncadin M, Pigorsch S, Metaxas M, Falzon M, Matthews A, Corica T, Williams NR, Baum M
- Issue date: 2010 Jul 10