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dc.contributor.authorRenehan, Andrew G
dc.contributor.authorGleave, E N
dc.contributor.authorHancock, B D
dc.contributor.authorSmith, P
dc.contributor.authorMcGurk, M
dc.date.accessioned2010-04-08T10:07:46Z
dc.date.available2010-04-08T10:07:46Z
dc.date.issued1996-12
dc.identifier.citationLong-term follow-up of over 1000 patients with salivary gland tumours treated in a single centre. 1996, 83 (12):1750-4 Br J Surgen
dc.identifier.issn0007-1323
dc.identifier.pmid9038559
dc.identifier.doi10.1002/bjs.1800831228
dc.identifier.urihttp://hdl.handle.net/10541/95978
dc.description.abstractBetween 1947 and 1992, 1403 patients with 1432 salivary gland tumours were treated at the Christie Hospital, Manchester. There were 1194 epithelial neoplasms: parotid, 1082 (91 per cent); submandibular, 47 (4 per cent); minor glands, 65 (5 per cent). The commonest histological diagnoses were pleomorphic adenoma (n = 776) and adenolymphoma (n = 159). A total of 244 carcinomas were seen (adenoid cystic carcinoma, n = 75). Treatment was primarily surgical, conservative where possible, and determined by tumour extent and not histology. Adjuvant radiation therapy was used in over half the definitively treated malignancies. The recurrence rate following the treatment of 551 new parotid pleomorphic adenomas was 1.6 per cent at median follow-up 12.5 (range 1-34) years, increasing to 15 per cent in the secondarily referred group (n = 170). For patients with definitively treated primary salivary carcinomas (n = 148), the disease-free survival rate at 5, 10 and 15 years was 58, 47 and 45 per cent respectively. Using multivariate analysis, clinical stage was the most important predictor of survival; the 10-year survival rate for stages I-IV was 96, 70, 47 and 19 per cent respectively.
dc.language.isoenen
dc.subject.meshAdenolymphoma
dc.subject.meshAdenoma, Pleomorphic
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAge Distribution
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshCarcinoma, Adenoid Cystic
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshDisease-Free Survival
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshReferral and Consultation
dc.subject.meshRisk Factors
dc.subject.meshSalivary Gland Neoplasms
dc.subject.meshSubmandibular Gland Neoplasms
dc.subject.meshSurvival Rate
dc.subject.meshTreatment Failure
dc.titleLong-term follow-up of over 1000 patients with salivary gland tumours treated in a single centre.en
dc.typeArticleen
dc.contributor.departmentUniversity Department of Surgery, University Hospital of South Manchester, UK.en
dc.identifier.journalThe British Journal of Surgeryen
html.description.abstractBetween 1947 and 1992, 1403 patients with 1432 salivary gland tumours were treated at the Christie Hospital, Manchester. There were 1194 epithelial neoplasms: parotid, 1082 (91 per cent); submandibular, 47 (4 per cent); minor glands, 65 (5 per cent). The commonest histological diagnoses were pleomorphic adenoma (n = 776) and adenolymphoma (n = 159). A total of 244 carcinomas were seen (adenoid cystic carcinoma, n = 75). Treatment was primarily surgical, conservative where possible, and determined by tumour extent and not histology. Adjuvant radiation therapy was used in over half the definitively treated malignancies. The recurrence rate following the treatment of 551 new parotid pleomorphic adenomas was 1.6 per cent at median follow-up 12.5 (range 1-34) years, increasing to 15 per cent in the secondarily referred group (n = 170). For patients with definitively treated primary salivary carcinomas (n = 148), the disease-free survival rate at 5, 10 and 15 years was 58, 47 and 45 per cent respectively. Using multivariate analysis, clinical stage was the most important predictor of survival; the 10-year survival rate for stages I-IV was 96, 70, 47 and 19 per cent respectively.


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