AffiliationDepartment of Pathology, Christie Hospital, Manchester.
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AbstractA unique case of a metastatic non-desmoplastic sarcomatoid malignant melanoma in an axillary lymph node showing smooth muscle differentiation in a 54 year old woman is described. The tumour cells exhibited alpha-smooth muscle actin, HHF-35 and desmin positivity but were negative for S100 protein and HMB-45. Ultrastructural examination revealed smooth muscle phenotype and there was no evidence of myofibroblastic differentiation, a feature described previously in desmoplastic melanomas.
CitationMalignant melanoma showing smooth muscle differentiation. 1996, 49 (11):950-1 J. Clin. Pathol.
JournalJournal of Clinical Pathology