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dc.contributor.authorMorphopoulos, G Den
dc.contributor.authorBanerjee, Saumitra Sen
dc.contributor.authorAli, H Hen
dc.contributor.authorStewart, Men
dc.contributor.authorVasudev, K Sen
dc.contributor.authorEyden, Brian Pen
dc.contributor.authorHarris, Martinen
dc.date.accessioned2010-04-08T11:49:45Z
dc.date.available2010-04-08T11:49:45Z
dc.date.issued1996-05
dc.identifier.citationMalignant peripheral nerve sheath tumour with vascular differentiation: a report of four cases. 1996, 28 (5):401-10 Histopathologyen
dc.identifier.issn0309-0167
dc.identifier.pmid8735715
dc.identifier.urihttp://hdl.handle.net/10541/95965
dc.description.abstractFour cases of malignant peripheral nerve sheath tumour showing vascular differentiation are described. One case was associated with neurofibromatosis 1 and contained angiosarcomatous, cartilaginous and rhabdomyoblastic elements. The other cases occurred in patients without neurofibromatosis and showed a spectrum of vascular lesions ranging from lobulated, haemangioma-like structures to angiosarcoma. These are the first recorded examples of this phenomenon not associated with neurofibromatosis. Immunohistochemical examination demonstrated the endothelial nature of the lesions in all cases and revealed cells positive for alpha-smooth muscle actin, probably pericytes, closely apposed to the endothelium.
dc.language.isoenen
dc.subjectHaemangiomaen
dc.subjectHaemangiosarcomaen
dc.subjectSecond Primary Canceren
dc.subjectNeuroectodermal Tumoursen
dc.subjectPeripheral Nervous System Canceren
dc.subjectVascular Canceren
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCell Differentiation
dc.subject.meshCell Transformation, Neoplastic
dc.subject.meshEndothelium, Vascular
dc.subject.meshFemale
dc.subject.meshHemangioma
dc.subject.meshHemangiosarcoma
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasms, Second Primary
dc.subject.meshNeurilemmoma
dc.subject.meshNeuroectodermal Tumors, Primitive, Peripheral
dc.subject.meshNeurofibromatosis 1
dc.subject.meshPeripheral Nervous System Neoplasms
dc.subject.meshVascular Neoplasms
dc.titleMalignant peripheral nerve sheath tumour with vascular differentiation: a report of four cases.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalHistopathologyen
html.description.abstractFour cases of malignant peripheral nerve sheath tumour showing vascular differentiation are described. One case was associated with neurofibromatosis 1 and contained angiosarcomatous, cartilaginous and rhabdomyoblastic elements. The other cases occurred in patients without neurofibromatosis and showed a spectrum of vascular lesions ranging from lobulated, haemangioma-like structures to angiosarcoma. These are the first recorded examples of this phenomenon not associated with neurofibromatosis. Immunohistochemical examination demonstrated the endothelial nature of the lesions in all cases and revealed cells positive for alpha-smooth muscle actin, probably pericytes, closely apposed to the endothelium.


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