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    Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36.

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    Authors
    Ning, Z Q
    Norton, John D
    Li, J
    Murphy, J J
    Affiliation
    Infection and Immunity Research group, King's College London, GB.
    Issue Date
    1996-10
    
    Metadata
    Show full item record
    Abstract
    The role of interleukin-4 (IL-4) and CD40 signaling in negative regulation of apoptosis in human Ramos B cells induced in response to different agents was investigated. CD40 ligation protected cells from apoptosis induced by calcium ionophore through an initial, rapid and apparently Bcl-2-independent mechanism, associated with up-regulation of Bcl-XL. However, rescue from apoptosis induced by inhibition of macromolecular synthesis required several hours of prior stimulation with CD40 ligand/antibody and was accompanied by up-regulation of Bcl-2. In contrast, IL-4 did not up-regulate Bcl-2 or Bcl-XL and did not inhibit apoptosis induced by inhibitors of macromolecular synthesis. However, IL-4 did protect Ramos cells from apoptosis induced by calcium ionophore and this effect was accompanied by inhibition of ionophore-induced expression of an immediate early gene encoding a 36-kDa zinc-finger protein, Berg36. Antisense blockade of Berg36 expression partially inhibited ionophore-induced apoptosis to an extent commensurate with the level of IL-4 protection, implicating Berg36 function as a requirement for apoptosis induced through calcium signaling and as a target for IL-4 through which this cytokine inhibits apoptosis in Ramos B cells. These distinct mechanisms for rescue from apoptosis by CD40 and IL-4 may help explain the co-operative roles of these T cell-derived signals for B cell survival.
    Citation
    Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36. 1996, 26 (10):2356-63 Eur. J. Immunol.
    Journal
    European Journal of Immunology
    URI
    http://hdl.handle.net/10541/95934
    DOI
    10.1002/eji.1830261013
    PubMed ID
    8898945
    Type
    Article
    Language
    en
    ISSN
    0014-2980
    ae974a485f413a2113503eed53cd6c53
    10.1002/eji.1830261013
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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