Increased serum lipoprotein(a) concentrations after growth hormone (GH) treatment in patients with isolated GH deficiency.
AffiliationDepartment of Endocrinology, Christie Hospital NHS Trust, Manchester, UK.
MetadataShow full item record
AbstractFourteen post-pubertal subjects (11 male, 3 female) with isolated growth hormone (GH) deficiency were treated with a low dose (0.125 U/kg for the first 4 weeks and thereafter 0.25 U/kg/week) daily sc GH injection for 1 year. Fasting blood samples were collected at entry into the study and subsequently at 3 monthly intervals for estimation of serum cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol and lipoprotein(a) [Lp(a)]. Serum Lp(a) increased progressively during the treatment period (by analysis of variance) and was 41% higher at 12 months (P < 0.02) despite the fact that five patients showed little or no change. There was no significant change in any of the other lipid fractions. These observations are of concern as Lp(a) is an independent risk factor for cardiovascular disease and should introduce a cautionary note into the enthusiastic efforts to offer GH replacement to all GH deficient adults.
CitationIncreased serum lipoprotein(a) concentrations after growth hormone (GH) treatment in patients with isolated GH deficiency. 1996, 33 ( Pt 4):330-4 Ann. Clin. Biochem.
JournalAnnals of Clinical Biochemistry
- The effect of recombinant human GH replacement therapy on lipoprotein(a) and other lipid parameters in adults with acquired GH deficiency: results of a double-blind and placebo-controlled trial.
- Authors: Nolte W, Rädisch C, Armstrong VW, Hüfner M, von zur Mühlen A
- Issue date: 1997 Nov
- Two weeks of daily injections and continuous infusion of recombinant human growth hormone (GH) in GH-deficient adults. II. Effects on serum lipoproteins and lipoprotein and hepatic lipase activity.
- Authors: Oscarsson J, Ottosson M, Johansson JO, Wiklund O, Mårin P, Björntorp P, Bengtsson BA
- Issue date: 1996 Mar
- Growth hormone (GH) replacement therapy reduces serum sialic acid concentrations in adults with GH-deficiency: a double-blind placebo-controlled study.
- Authors: Christ ER, Cummings MH, Lumb PJ, Crook MA, Sönksen PH, Russell-Jones DL
- Issue date: 1999 Aug
- Low dose continuously infused growth hormone results in increased lipoprotein(a) and decreased low density lipoprotein cholesterol concentrations in middle-aged men.
- Authors: Oscarsson J, Ottosson M, Wiklund O, Mårin P, Vikman-Adolfsson K, Björntorp P, Edén S
- Issue date: 1994 Jul
- Sustained reduction in circulating cholesterol in adult hypopituitary patients given low dose titrated growth hormone replacement therapy: a two year study.
- Authors: Florakis D, Hung V, Kaltsas G, Coyte D, Jenkins PJ, Chew SL, Grossman AB, Besser GM, Monson JP
- Issue date: 2000 Oct