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    Novel asymmetric photosensitizers: an in vitro study.

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    Authors
    Haylett, Ann K
    Forbes, E
    MacLennan, A
    Truscott, T G
    Moore, James V
    Affiliation
    Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Manchester, UK.
    Issue Date
    1996-08-02
    
    Metadata
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    Abstract
    A series of compounds based on an asymmetrical protoporphyrin molecule have been examined. The paired groups of sensitizers differed in terms of the presence or absence of a permanent positive charge, in the alkyl side chain length and in having either a primary or secondary amine substituent. The effects of these variables on drug uptake, partition coefficient and photodynamic cell kill were tested. Drug uptake and partition coefficient were shown to be correlated. Differences in gross uptake were found within paired groups of sensitizers although cell-associated uptake alone did not correlate with clonogenic cell survival. Of the compounds tested it was the sensitizers with alkyl side chains, rather than the permanently positively charged compounds, which resulted in the greatest degree of clonogenic cell kill.
    Citation
    Novel asymmetric photosensitizers: an in vitro study. 1996, 105 (2):187-93 Cancer Lett.
    Journal
    Cancer Letters
    URI
    http://hdl.handle.net/10541/95847
    DOI
    10.1016/0304-3835(96)04279-6
    PubMed ID
    8697443
    Type
    Article
    Language
    en
    ISSN
    0304-3835
    ae974a485f413a2113503eed53cd6c53
    10.1016/0304-3835(96)04279-6
    Scopus Count
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    All Paterson Institute for Cancer Research

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