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    Response of V79 cells to low doses of X-rays and negative pi-mesons: clonogenic survival and DNA strand breaks.

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    Authors
    Marples, Brian
    Adomat, H
    Koch, C J
    Skov, K A
    Affiliation
    Medical Biophysics, BC Cancer Research Centre, Vancouver, Canada.
    Issue Date
    1996-10
    
    Metadata
    Show full item record
    Abstract
    Mammalian cells are hypersensitive to very low doses of X-rays (< 0.2 Gy), a response which is followed by increased radioresistance up to 1 Gy. Increased radioresistance is postulated to be a response to DNA damage, possibly single-strand breaks, and it appears to be a characteristic of low linear energy transfer (LET) radiation. Here we demonstrate a correspondence between the extent of the increased radioresistance and linear energy transfer of 250 kVp X-rays and plateau and Bragg peak negative pi-mesons. The results support our hypothesis since the size of the increased radioresistant response appears to correspond to the number of radiation induced single-strand breaks. Furthermore, since survival prior to the increased radioresistant response (< 0.2 Gy) was LET-independent, these data support the notion that the increased radioresistant response may dictate the overall survival response to higher doses. However, while these data provide further circumstantial evidence for the involvement of DNA strand breaks in the triggering of increased radioresistance, more direct conclusions cannot be made. The data are not accurate enough to detect structure in the single-strand break profiles, the production of single-strand breaks being apparently linear with dose.
    Citation
    Response of V79 cells to low doses of X-rays and negative pi-mesons: clonogenic survival and DNA strand breaks. 1996, 70 (4):429-36 Int. J. Radiat. Biol.
    Journal
    International Journal of Radiation Biology
    URI
    http://hdl.handle.net/10541/95840
    DOI
    10.1080/095530096144905
    PubMed ID
    8862454
    Type
    Article
    Language
    en
    ISSN
    0955-3002
    ae974a485f413a2113503eed53cd6c53
    10.1080/095530096144905
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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