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    Exposure to extremely low frequency magnetic fields has no effect on growth rate or clonogenic potential of multipotential haemopoietic progenitor cells.

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    Authors
    Reipert, Brigit M
    Allan, Donald
    Dexter, T Michael
    Affiliation
    Cancer Research Campaign Department of Physics & Instrumentation, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
    Issue Date
    1996
    
    Metadata
    Show full item record
    Abstract
    Recent reports indicate an increased risk of acute myeloid leukaemia in children exposed to extremely low frequency magnetic fields (ELFMFs) emitted by high voltage power lines, suggesting that ELFMFs may act as weak tumour promoters. We have investigated possible interactions of weak ELFMFs with primitive haemopoietic cells in vitro using the multipotential progenitor cell line FDCP-mix(A4). We have determined the proliferative activity and clonogenic potential of cells under both optimal and sub-optimal growth conditions and exposed to either ambient laboratory ELFMFs or three other ELFMF regimes representative of those produced by high voltage power lines: nulled fields, Ca2+-ion cyclotron resonance conditions at 50 Hz, and vertical 50 Hz fields of 6 muT(RMS). Using exposures of 1, 4, 7 and 21 days, we found no significant alteration of growth rate, cell-cycle state or clonogenic efficiency indicating that neither the proliferation nor self-renewal of multipotential FDCP-mix(A4) cells was perturbed.
    Citation
    Exposure to extremely low frequency magnetic fields has no effect on growth rate or clonogenic potential of multipotential haemopoietic progenitor cells. 1996, 13 (3-4):205-17 Growth Factors
    Journal
    Growth Factors
    URI
    http://hdl.handle.net/10541/95809
    DOI
    10.3109/08977199609003222
    PubMed ID
    8919028
    Type
    Article
    Language
    en
    ISSN
    0897-7194
    ae974a485f413a2113503eed53cd6c53
    10.3109/08977199609003222
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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